Lack of dopaminergic modulation of cognitive flexibility

Shawn F. Smyth, David Q. Beversdorf

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVE: To evaluate performance on a cognitive flexibility task after administration of a dopaminergic agonist. BACKGROUND: L-3,4- dihydroxyphenylalanine, which is converted into dopamine and norepinephrine, results in a restriction of the semantic network in priming experiments. Recent evidence suggests that flexibility of access to semantic networks in problem solving is mediated by the noradrenergic system. We wished to determine if dopaminergic agonists also affect this type of cognitive flexibility. METHODS: Eighty-four subjects were tested twice on an anagram task, once 1 hour after bromocriptine (dopamine agonist) and once 1 hour after placebo administration. RESULTS: No difference was detected between placebo and bromocriptine on anagram performance. CONCLUSIONS: Therefore, modulation of this type of cognitive flexibility does not seem to be mediated by the dopaminergic system. This suggests that the noradrenergic modulation of cognitive flexibility previously reported does not seem to extend to the dopaminergic system among catecholamines.

Original languageEnglish (US)
Pages (from-to)225-229
Number of pages5
JournalCognitive and Behavioral Neurology
Volume20
Issue number4
DOIs
StatePublished - Dec 2007
Externally publishedYes

Keywords

  • Catecholamine
  • Cognitive flexibility
  • Creativity
  • Dopaminergic
  • Noradrenergic
  • Problem solving
  • Semantic

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Psychiatry and Mental health

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