TY - JOUR
T1 - Lack of CXCR3 delays the development of hepatic inflammation but does not impair resistance to Leishmania donovani
AU - Barbi, Joseph
AU - Oghumu, Steve
AU - Rosas, Lucia E.
AU - Carlson, Tracy
AU - Lu, Bao
AU - Gerard, Craig
AU - Lezama-Oavila, Claudio M.
AU - Satoskar, Abhay R.
N1 - Funding Information:
Received 28 September 2006; accepted 21 November 2006; electronically published 16 April 2007. Potential conflicts of interest: none reported. Presented in part: ASTMH, 55th Annual Meeting, Atlanta, November 2006; Woods Hole Immunoparasitology Meeting, Woods Hole, April 2007. Financial support: National Institutes of Health (grant AI51328). Reprints or correspondence: Dr. Abhay R. Satoskar, Dept. of Microbiology, The Ohio State University, 484 W. 12th Ave., Columbus, OH 43221 (satoskar.2@osu.edu).
PY - 2007/6/1
Y1 - 2007/6/1
N2 - CXC chemokine receptor 3 (CXCR3) ligands CXCL9 and CXCL10 are produced at high levels in mice and humans infected with Leishmania donovani, but their contribution to host resistance against L. donovani is not clear. Here, using CXCR3-/- mice, we demonstrate that, although CXCR3 regulates early immune cell trafficking and hepatic inflammation during L. donovani infection, it is not essential for immunity against L. donovani, unlike L. major. CXCR3-/- C57BL/6 mice show a delayed onset of hepatic inflammation and granuloma formation after L. donovani infection. However, they mount an efficient T helper cell type 1 response, recruit T cells to the liver, and control parasite growth as efficiently as do CXCR3+/+ C57BL/6 mice.
AB - CXC chemokine receptor 3 (CXCR3) ligands CXCL9 and CXCL10 are produced at high levels in mice and humans infected with Leishmania donovani, but their contribution to host resistance against L. donovani is not clear. Here, using CXCR3-/- mice, we demonstrate that, although CXCR3 regulates early immune cell trafficking and hepatic inflammation during L. donovani infection, it is not essential for immunity against L. donovani, unlike L. major. CXCR3-/- C57BL/6 mice show a delayed onset of hepatic inflammation and granuloma formation after L. donovani infection. However, they mount an efficient T helper cell type 1 response, recruit T cells to the liver, and control parasite growth as efficiently as do CXCR3+/+ C57BL/6 mice.
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U2 - 10.1086/516787
DO - 10.1086/516787
M3 - Article
C2 - 17471442
AN - SCOPUS:34249093547
SN - 0022-1899
VL - 195
SP - 1713
EP - 1717
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 11
ER -