TY - JOUR
T1 - Lack of cross-reactivity between aztreonam, a monobactam antibiotic, and penicillin in penicillin-allergic subjects
AU - Saxon, Andrew
AU - Hassner, Avi
AU - Swabb, Edward A.
AU - Wheeler, Barbara
AU - Adkinson, N. Franklin
N1 - Funding Information:
Received for publication June 1, 1983, and in revised form August 29, 1983. All subjects provided written informed consent after written disclosure of the nature and potential risks of the study. The protocol for the study was approved by the Human Subjects Protection Committee of the University of California, Los Angeles, and The Johns Hopkins Joint Committee on Clinical Investigation. This work was supported in part by a grant from the Squibb Institute for Medical Research. Dr Saxon was the recipient of Allergic Diseases Academic Award AI-00326 from the National Institutes of Allergy and Infectious Diseases. Dr Hassner was the recipient of a Rothschild Foundation Fellowship and a grant from the Asthma and Allergy Foundation of America (Los Angeles Chapter). We thank Helen Ferenchik and Rhonda Crosby for their assistance in performing the skin tests. Please address requests for reprints to Dr Andrew Saxon, Division of Clinical Immunology/Allergy, Department of Medicine, School of Medicine, University of California, Los Angeles, California 90024.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1984
Y1 - 1984
N2 - Monobactam antibiotics are a new class of β-lactam antibiotics. In contrast to penicillins or cephalosporins, monobactams possess a monocyclic β-lactam structure. IgE or immediate hypersensitivity cross-reactivity between aztreonam (a monobactam) and penicillin was investigated, since this will be an important consideration when therapy is chosen. The maximum concentration of aztreonam reagents not giving false-positive skin tests was determined in normal subjects who were not allergic to penicillin. Subsequently, 41 subjects with IgE antibody to one or more penicillin moieties, as determined by positive skin reactions, were tested with the aztreonam reagents. Thirty-seven of these persons showed no reactivity while four showed equivocal tests. Repeat tests in those four persons were negative to the aztreonam reagents, while their penicillin tests remained unchanged. These in vivo data suggest that there is no cross-reactivity between IgE antibodies to penicillin and aztreonam and provide a basis for investigating the therapeutic use of monobactams in patients who are allergic to penicillin.
AB - Monobactam antibiotics are a new class of β-lactam antibiotics. In contrast to penicillins or cephalosporins, monobactams possess a monocyclic β-lactam structure. IgE or immediate hypersensitivity cross-reactivity between aztreonam (a monobactam) and penicillin was investigated, since this will be an important consideration when therapy is chosen. The maximum concentration of aztreonam reagents not giving false-positive skin tests was determined in normal subjects who were not allergic to penicillin. Subsequently, 41 subjects with IgE antibody to one or more penicillin moieties, as determined by positive skin reactions, were tested with the aztreonam reagents. Thirty-seven of these persons showed no reactivity while four showed equivocal tests. Repeat tests in those four persons were negative to the aztreonam reagents, while their penicillin tests remained unchanged. These in vivo data suggest that there is no cross-reactivity between IgE antibodies to penicillin and aztreonam and provide a basis for investigating the therapeutic use of monobactams in patients who are allergic to penicillin.
UR - http://www.scopus.com/inward/record.url?scp=0021368586&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021368586&partnerID=8YFLogxK
U2 - 10.1093/infdis/149.1.16
DO - 10.1093/infdis/149.1.16
M3 - Article
C2 - 6537963
AN - SCOPUS:0021368586
SN - 0022-1899
VL - 149
SP - 16
EP - 22
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 1
ER -