Lack of consistent relationship between quantity of aluminum in diphtheria-tetanus-acellular pertussis vaccines and rates of extensive swelling reactions

Margaret B. Rennels; Maria Deloria Knoll; Michael E. Pichichero; Janet A. Englund; Edwin L. Anderson; Mark C. Steinhoff; Michael D. Decker; Kathryn M. Edwards

doi:10.1016/S0264-410X(02)00128-7

Lack of consistent relationship between quantity of aluminum in diphtheria-tetanus-acellular pertussis vaccines and rates of extensive swelling reactions

Margaret B. Rennels, Maria Deloria Knoll, Michael E. Pichichero, Janet A. Englund, Edwin L. Anderson, Mark C. Steinhoff, Michael D. Decker, Kathryn M. Edwards

Research output: Contribution to journal › Article › peer-review

Abstract

The precise role that aluminum plays in local reactogenicity is not clear. We explored the relationship between rates of severe local reactions following the fourth and fifth booster doses of several diphtheria-tetanus-acellular pertussis vaccines (DTaP) and the quantity of aluminum contained in the different vaccines. Although there was a significant relationship between higher aluminum contents and swelling reactions >50mm after dose 5, no relationship was seen with entire thigh swelling or with swelling >50mm after dose 4. Because of the inconsistency of the data, a dose response between local reactogenicity and aluminum is questionable.

Original language	English (US)
Journal	Vaccine
Volume	20
Issue number	SUPPL. 3
DOIs	https://doi.org/10.1016/S0264-410X(02)00128-7
State	Published - May 31 2002
Externally published	Yes

Keywords

Adsorbed
Aluminum
Vaccines

ASJC Scopus subject areas

Immunology
Microbiology
Virology
Infectious Diseases
Public Health, Environmental and Occupational Health
General Veterinary

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10.1016/S0264-410X(02)00128-7

Cite this

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title = "Lack of consistent relationship between quantity of aluminum in diphtheria-tetanus-acellular pertussis vaccines and rates of extensive swelling reactions",

abstract = "The precise role that aluminum plays in local reactogenicity is not clear. We explored the relationship between rates of severe local reactions following the fourth and fifth booster doses of several diphtheria-tetanus-acellular pertussis vaccines (DTaP) and the quantity of aluminum contained in the different vaccines. Although there was a significant relationship between higher aluminum contents and swelling reactions >50mm after dose 5, no relationship was seen with entire thigh swelling or with swelling >50mm after dose 4. Because of the inconsistency of the data, a dose response between local reactogenicity and aluminum is questionable.",

keywords = "Adsorbed, Aluminum, Vaccines",

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T1 - Lack of consistent relationship between quantity of aluminum in diphtheria-tetanus-acellular pertussis vaccines and rates of extensive swelling reactions

AU - Rennels, Margaret B.

AU - Knoll, Maria Deloria

AU - Pichichero, Michael E.

AU - Englund, Janet A.

AU - Anderson, Edwin L.

AU - Steinhoff, Mark C.

AU - Decker, Michael D.

AU - Edwards, Kathryn M.

PY - 2002/5/31

Y1 - 2002/5/31

N2 - The precise role that aluminum plays in local reactogenicity is not clear. We explored the relationship between rates of severe local reactions following the fourth and fifth booster doses of several diphtheria-tetanus-acellular pertussis vaccines (DTaP) and the quantity of aluminum contained in the different vaccines. Although there was a significant relationship between higher aluminum contents and swelling reactions >50mm after dose 5, no relationship was seen with entire thigh swelling or with swelling >50mm after dose 4. Because of the inconsistency of the data, a dose response between local reactogenicity and aluminum is questionable.

AB - The precise role that aluminum plays in local reactogenicity is not clear. We explored the relationship between rates of severe local reactions following the fourth and fifth booster doses of several diphtheria-tetanus-acellular pertussis vaccines (DTaP) and the quantity of aluminum contained in the different vaccines. Although there was a significant relationship between higher aluminum contents and swelling reactions >50mm after dose 5, no relationship was seen with entire thigh swelling or with swelling >50mm after dose 4. Because of the inconsistency of the data, a dose response between local reactogenicity and aluminum is questionable.

KW - Adsorbed

KW - Aluminum

KW - Vaccines

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DO - 10.1016/S0264-410X(02)00128-7

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VL - 20

JO - Vaccine

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IS - SUPPL. 3

ER -

Lack of consistent relationship between quantity of aluminum in diphtheria-tetanus-acellular pertussis vaccines and rates of extensive swelling reactions

Abstract

Keywords

ASJC Scopus subject areas

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