Lack of cardiovascular tolerance during intravenous cocaine infusions in human volunteers

Karen Kumor, Michael Sherer, Loren Thompson, Edward Cone, J. Mahaffey, Jerome H. Jaffe

Research output: Contribution to journalArticlepeer-review

Abstract

Acute tolerance to the cardiovascular effects of cocaine has been hypothesized from experiments in which the plasma concentrations of cocaine were rapidly changing. We studied the cardiovascular responses of 8 male human subjects for 4 hours following intravenous bolus doses of cocaine, and compared these to responses in the same subjects after intravenous bolus doses of cocaine followed by continuous intravenous infusions of cocaine designed to maintain steady state plasma levels of cocaine. We found little evidence of tolerance to the tachycardia and hypertensive effects of cocaine during a four hour exposure. Lack of tolerance to the cardiovascular effects of cocaine may be a factor in some types of cocaine related toxicity among cocaine abusers.

Original languageEnglish (US)
Pages (from-to)2063-2071
Number of pages9
JournalLife Sciences
Volume42
Issue number21
DOIs
StatePublished - 1988

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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