Lack of association of the apoE4 allele with hippocampal sclerosis dementia

Juan C Troncoso, Claudia H. Kawas, Craig K. Chang, Marshal F. Folstein, John C. Hedreen

Research output: Contribution to journalArticle

Abstract

We determined the apolipoprotein E4 (apoE) genotype in 12 cases of autopsy-confirmed hippocampal sclerosis dementia (HSD), a disorder characterized pathologically by neuronal degeneration, predominantly of temporal lobe structures, without senile plaques or neurofibrillary tangles. The frequency of the apoE4 allele in HSD was 12.5%, similar to that of a control population and significantly different from the ~40% found in Alzheimer's disease (AD) (P <0.001). These observations suggest that apoE4 is not a risk factor for HSD.

Original languageEnglish (US)
Pages (from-to)138-140
Number of pages3
JournalNeuroscience Letters
Volume204
Issue number1-2
DOIs
StatePublished - Feb 2 1996

Fingerprint

Apolipoprotein E4
Sclerosis
Dementia
Alleles
Neurofibrillary Tangles
Amyloid Plaques
Temporal Lobe
Gene Frequency
Autopsy
Alzheimer Disease
Genotype
Population

Keywords

  • Aging
  • Alzheimer's disease
  • Frontal lobe dementia
  • Neurodegeneration

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Lack of association of the apoE4 allele with hippocampal sclerosis dementia. / Troncoso, Juan C; Kawas, Claudia H.; Chang, Craig K.; Folstein, Marshal F.; Hedreen, John C.

In: Neuroscience Letters, Vol. 204, No. 1-2, 02.02.1996, p. 138-140.

Research output: Contribution to journalArticle

Troncoso, Juan C ; Kawas, Claudia H. ; Chang, Craig K. ; Folstein, Marshal F. ; Hedreen, John C. / Lack of association of the apoE4 allele with hippocampal sclerosis dementia. In: Neuroscience Letters. 1996 ; Vol. 204, No. 1-2. pp. 138-140.
@article{c5dc119733e548bab554812c0bceb117,
title = "Lack of association of the apoE4 allele with hippocampal sclerosis dementia",
abstract = "We determined the apolipoprotein E4 (apoE) genotype in 12 cases of autopsy-confirmed hippocampal sclerosis dementia (HSD), a disorder characterized pathologically by neuronal degeneration, predominantly of temporal lobe structures, without senile plaques or neurofibrillary tangles. The frequency of the apoE4 allele in HSD was 12.5{\%}, similar to that of a control population and significantly different from the ~40{\%} found in Alzheimer's disease (AD) (P <0.001). These observations suggest that apoE4 is not a risk factor for HSD.",
keywords = "Aging, Alzheimer's disease, Frontal lobe dementia, Neurodegeneration",
author = "Troncoso, {Juan C} and Kawas, {Claudia H.} and Chang, {Craig K.} and Folstein, {Marshal F.} and Hedreen, {John C.}",
year = "1996",
month = "2",
day = "2",
doi = "10.1016/0304-3940(96)12331-4",
language = "English (US)",
volume = "204",
pages = "138--140",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "1-2",

}

TY - JOUR

T1 - Lack of association of the apoE4 allele with hippocampal sclerosis dementia

AU - Troncoso, Juan C

AU - Kawas, Claudia H.

AU - Chang, Craig K.

AU - Folstein, Marshal F.

AU - Hedreen, John C.

PY - 1996/2/2

Y1 - 1996/2/2

N2 - We determined the apolipoprotein E4 (apoE) genotype in 12 cases of autopsy-confirmed hippocampal sclerosis dementia (HSD), a disorder characterized pathologically by neuronal degeneration, predominantly of temporal lobe structures, without senile plaques or neurofibrillary tangles. The frequency of the apoE4 allele in HSD was 12.5%, similar to that of a control population and significantly different from the ~40% found in Alzheimer's disease (AD) (P <0.001). These observations suggest that apoE4 is not a risk factor for HSD.

AB - We determined the apolipoprotein E4 (apoE) genotype in 12 cases of autopsy-confirmed hippocampal sclerosis dementia (HSD), a disorder characterized pathologically by neuronal degeneration, predominantly of temporal lobe structures, without senile plaques or neurofibrillary tangles. The frequency of the apoE4 allele in HSD was 12.5%, similar to that of a control population and significantly different from the ~40% found in Alzheimer's disease (AD) (P <0.001). These observations suggest that apoE4 is not a risk factor for HSD.

KW - Aging

KW - Alzheimer's disease

KW - Frontal lobe dementia

KW - Neurodegeneration

UR - http://www.scopus.com/inward/record.url?scp=0030020311&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030020311&partnerID=8YFLogxK

U2 - 10.1016/0304-3940(96)12331-4

DO - 10.1016/0304-3940(96)12331-4

M3 - Article

VL - 204

SP - 138

EP - 140

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 1-2

ER -