Lack of association of the apoE4 allele with hippocampal sclerosis dementia

Juan C. Troncoso, Claudia H. Kawas, Craig K. Chang, Marshal F. Folstein, John C. Hedreen

Research output: Contribution to journalArticle


We determined the apolipoprotein E4 (apoE) genotype in 12 cases of autopsy-confirmed hippocampal sclerosis dementia (HSD), a disorder characterized pathologically by neuronal degeneration, predominantly of temporal lobe structures, without senile plaques or neurofibrillary tangles. The frequency of the apoE4 allele in HSD was 12.5%, similar to that of a control population and significantly different from the ~40% found in Alzheimer's disease (AD) (P < 0.001). These observations suggest that apoE4 is not a risk factor for HSD.

Original languageEnglish (US)
Pages (from-to)138-140
Number of pages3
JournalNeuroscience Letters
Issue number1-2
StatePublished - Feb 2 1996



  • Aging
  • Alzheimer's disease
  • Frontal lobe dementia
  • Neurodegeneration

ASJC Scopus subject areas

  • Neuroscience(all)

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