@article{c5dc119733e548bab554812c0bceb117,
title = "Lack of association of the apoE4 allele with hippocampal sclerosis dementia",
abstract = "We determined the apolipoprotein E4 (apoE) genotype in 12 cases of autopsy-confirmed hippocampal sclerosis dementia (HSD), a disorder characterized pathologically by neuronal degeneration, predominantly of temporal lobe structures, without senile plaques or neurofibrillary tangles. The frequency of the apoE4 allele in HSD was 12.5%, similar to that of a control population and significantly different from the ~40% found in Alzheimer's disease (AD) (P < 0.001). These observations suggest that apoE4 is not a risk factor for HSD.",
keywords = "Aging, Alzheimer's disease, Frontal lobe dementia, Neurodegeneration",
author = "Troncoso, {Juan C.} and Kawas, {Claudia H.} and Chang, {Craig K.} and Folstein, {Marshal F.} and Hedreen, {John C.}",
note = "Funding Information: age of onset 68.7 year,,;)a nd comparedth eirapoE4 allele frequency with published data for controls \[17\]a nd autopsy-confirmesdp oradicA D \[21\i]n cludingo ur own seriesf rom the Alzheinaer'Ds iseaseR esearchC enter\[5\] (see Table 1). The fi:equencyo f apoE4 in HSD was 12.5%, almost identical to that of a Caucasianc ontrol population\ [17\]a, nd significantlyd ifferent(P<0.001) from apoE4 frequencyin AD \[5,21\]. Our observationisn dicaten o associationo f apoE4 allele with HSD, suggestintgh atapoE4 is neithera risk nor a pathogenicfa ctor fi~r HSD. Although HSD and AD share a common patterno f neuronadl egenerationth, eir differencesin amyloid deposits/senilpel aques,neurofibrillary tangles,a nd ~sociationw ith apoE4 lead us to believet hatHSD and AD are biologicallyd ifferentd isor-ders. Finally, from a nosologicapl erspectivei,t appears attractivet o group HSD with the lobar atrophy/frontal lobe type of dementiaw, hichalso is characterizebdy lack of amyloid depositsa nd no associationw ith the apoE4 allele \[20\]. The authorst hankMs. Kathryn A. Carson,M aria Cor-rada, and Dr. Ronald Brookmeyefro r assistancwe ith statistics and helpful discussionsW. e also thank Mr. Anthony Costello and Mrs. Gay Rudow for excellentte chni-cal assistanceT. his work was supportedb y funds from the US Public Health Service( AG 05146,A G 08325,A G 07914), the Charles A. Dana Foundationa, nd the Alzheimer'sA ssociation.",
year = "1996",
month = feb,
day = "2",
doi = "10.1016/0304-3940(96)12331-4",
language = "English (US)",
volume = "204",
pages = "138--140",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "1-2",
}