Lack of association of herpes simplex virus type 2 seropositivity with the progression of HIV infection in the HERS cohort

Brooke E. Hoots, Michael G. Hudgens, Stephen R. Cole, Caroline C. King, Robert S. Klein, Kenneth H. Mayer, Anne M. Rompalo, Jack D. Sobel, Denise J. Jamieson, Jennifer S. Smith

Research output: Contribution to journalArticle

Abstract

Many studies have chronicled the "epidemiologic synergy" between human immunodeficiency virus (HIV) and herpes simplex virus type 2 (HSV-2). HIV adversely affects the natural history of HSV-2 and results in more frequent and severe HSV-2 reactivation. Few longitudinal studies, however, have examined whether HSV-2 is associated with increased HIV plasma viral loads or decreased CD4 counts. The authors estimated the effect of HSV-2 seropositivity on HIV RNA viral load and on CD4 count over time among 777 HIV-seropositive US women not receiving suppressive HSV-2 therapy in the HIV Epidemiology Research Study (1993-2000). Linear mixed models were used to assess the effect of HSV-2 on log HIV viral load and CD4 count/mm3 prior to widespread initiation of highly active antiretroviral therapy. Coinfection with HSV-2 was not associated with HIV RNA plasma viral loads during study follow-up. There was a statistically significant association between HSV-2 seropositivity and CD4 count over time, but this difference was small and counterintuitive at an increase of 8 cells/mm3 (95% confidence interval: 2, 14) per year among HSV-2-seropositive women compared with HSV-2-seronegative women. These data do not support a clinically meaningful effect of baseline HSV-2 seropositivity on the trajectories of HIV plasma viral loads or CD4 counts.

Original languageEnglish (US)
Pages (from-to)837-844
Number of pages8
JournalAmerican journal of epidemiology
Volume173
Issue number7
DOIs
StatePublished - Apr 1 2011

Keywords

  • CD4 lymphocyte count
  • HIV
  • herpes simplex
  • herpesvirus 2, human
  • viral load

ASJC Scopus subject areas

  • Epidemiology

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    Hoots, B. E., Hudgens, M. G., Cole, S. R., King, C. C., Klein, R. S., Mayer, K. H., Rompalo, A. M., Sobel, J. D., Jamieson, D. J., & Smith, J. S. (2011). Lack of association of herpes simplex virus type 2 seropositivity with the progression of HIV infection in the HERS cohort. American journal of epidemiology, 173(7), 837-844. https://doi.org/10.1093/aje/kwq432