Lack of association between the pancreatitis risk allele CEL-HYB and pancreatic cancer

Koji Shindo, Jun Yu, Masaya Suenaga, Shahriar Fesharakizadeh, Koji Tamura, Jose Alejandro Navarro Almario, Aaron Brant, Michael Borges, Abdulrehman Siddiqui, Lisa Datta, Christopher L. Wolfgang, Ralph H. Hruban, Alison Patricia Klein, Michael Goggins

Research output: Contribution to journalArticle

Abstract

CEL-HYB is a hybrid allele that arose from a crossover between the 3' end of the Carboxyl ester lipase (CEL) gene and the nearby CEL pseudogene (CELP) and was recently identified as a risk factor for chronic pancreatitis. Since chronic pancreatitis is a risk factor for the development of pancreatic cancer, we compared the prevalence of the CEL-HYB allele in patients with pancreatic ductal adenocarcinoma to spousal controls and disease controls. The CEL-HYB allele was detected using Sanger and next generation sequencing. There was no significant difference in the prevalence of the CEL-HYB allele between cases with pancreatic ductal adenocarcinoma compared to controls; 2.6% (22/850) vs. 1.8% (18/976) (p=0.35). CEL-HYB carriers were not more likely to report a history of pancreatitis. Patients with pancreatic cancer are not more likely than controls to be carriers of the CEL-HYB allele.

Original languageEnglish (US)
Pages (from-to)50824-50831
Number of pages8
JournalOncotarget
Volume8
Issue number31
DOIs
StatePublished - Feb 7 2017

Keywords

  • CEL
  • CEL-HYB
  • CELP
  • Chronic pancreatitis
  • Pancreatic cancer

ASJC Scopus subject areas

  • Oncology

Fingerprint Dive into the research topics of 'Lack of association between the pancreatitis risk allele CEL-HYB and pancreatic cancer'. Together they form a unique fingerprint.

  • Cite this