Lack of association between the pancreatitis risk allele CEL-HYB and pancreatic cancer

Koji Shindo, Jun Yu, Masaya Suenaga, Shahriar Fesharakizadeh, Koji Tamura, Jose Alejandro Navarro Almario, Aaron Brant, Michael Borges, Abdulrehman Siddiqui, Lisa Datta, Christopher Wolfgang, Ralph H Hruban, Alison Klein, Michael S Goggins

Research output: Contribution to journalArticle

Abstract

CEL-HYB is a hybrid allele that arose from a crossover between the 3' end of the Carboxyl ester lipase (CEL) gene and the nearby CEL pseudogene (CELP) and was recently identified as a risk factor for chronic pancreatitis. Since chronic pancreatitis is a risk factor for the development of pancreatic cancer, we compared the prevalence of the CEL-HYB allele in patients with pancreatic ductal adenocarcinoma to spousal controls and disease controls. The CEL-HYB allele was detected using Sanger and next generation sequencing. There was no significant difference in the prevalence of the CEL-HYB allele between cases with pancreatic ductal adenocarcinoma compared to controls; 2.6% (22/850) vs. 1.8% (18/976) (p=0.35). CEL-HYB carriers were not more likely to report a history of pancreatitis. Patients with pancreatic cancer are not more likely than controls to be carriers of the CEL-HYB allele.

Original languageEnglish (US)
Pages (from-to)50824-50831
Number of pages8
JournalOncotarget
Volume8
Issue number31
DOIs
StatePublished - Feb 7 2017

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Lipase
Pancreatic Neoplasms
Pancreatitis
Esters
Alleles
Chronic Pancreatitis
Adenocarcinoma
Pseudogenes
Genes

Keywords

  • CEL
  • CEL-HYB
  • CELP
  • Chronic pancreatitis
  • Pancreatic cancer

ASJC Scopus subject areas

  • Oncology

Cite this

Lack of association between the pancreatitis risk allele CEL-HYB and pancreatic cancer. / Shindo, Koji; Yu, Jun; Suenaga, Masaya; Fesharakizadeh, Shahriar; Tamura, Koji; Almario, Jose Alejandro Navarro; Brant, Aaron; Borges, Michael; Siddiqui, Abdulrehman; Datta, Lisa; Wolfgang, Christopher; Hruban, Ralph H; Klein, Alison; Goggins, Michael S.

In: Oncotarget, Vol. 8, No. 31, 07.02.2017, p. 50824-50831.

Research output: Contribution to journalArticle

Shindo, K, Yu, J, Suenaga, M, Fesharakizadeh, S, Tamura, K, Almario, JAN, Brant, A, Borges, M, Siddiqui, A, Datta, L, Wolfgang, C, Hruban, RH, Klein, A & Goggins, MS 2017, 'Lack of association between the pancreatitis risk allele CEL-HYB and pancreatic cancer', Oncotarget, vol. 8, no. 31, pp. 50824-50831. https://doi.org/10.18632/oncotarget.15137
Shindo K, Yu J, Suenaga M, Fesharakizadeh S, Tamura K, Almario JAN et al. Lack of association between the pancreatitis risk allele CEL-HYB and pancreatic cancer. Oncotarget. 2017 Feb 7;8(31):50824-50831. https://doi.org/10.18632/oncotarget.15137
Shindo, Koji ; Yu, Jun ; Suenaga, Masaya ; Fesharakizadeh, Shahriar ; Tamura, Koji ; Almario, Jose Alejandro Navarro ; Brant, Aaron ; Borges, Michael ; Siddiqui, Abdulrehman ; Datta, Lisa ; Wolfgang, Christopher ; Hruban, Ralph H ; Klein, Alison ; Goggins, Michael S. / Lack of association between the pancreatitis risk allele CEL-HYB and pancreatic cancer. In: Oncotarget. 2017 ; Vol. 8, No. 31. pp. 50824-50831.
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