Lack of association between chronic exposure to biomass fuel smoke and markers of right ventricular pressure overload at high altitude

Maria A. Caravedo, Matthew S. Painschab, Victor G. Davila-Roman, Aldo De Ferrari, Robert H. Gilman, Angel D. Vasquez-Villar, Suzanne L. Pollard, J. Jaime Miranda, William Checkley

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Chronic exposure to biomass fuel smoke has been implicated in the development of pulmonary hypertension and right ventricular pressure/volume overload through activation of inflammation, increase in vascular resistance, and endothelial dysfunction. We sought to compare N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) and echocardiography-derived pulmonary artery systolic pressure (PASP) levels in a high-altitude population-based study in Peru with and without chronic exposure to biomass fuel smoke.

Methods: NT-pro-BNP levels were measured in 519 adults (275 with and 244 without chronic exposure to biomass fuel smoke). Participants answered sociodemographics and clinical history questionnaires, underwent a clinical examination and blood testing for cardiopulmonary biomarkers. PASP was measured in a subgroup of 153 (31%) subjects.

Results: The study group consisted of 280 men (54%) and 239 women (46%). Average age was 56 years and average body mass index was 27 kg/m2. In multivariable analysis, there was no association between chronic exposure to biomass fuel smoke and NT-pro-BNP (P =.31) or PASP (P =.31). In the subgroup in which both NT-pro-BNP levels and PASP were measured, there was strong evidence of an association between these two variables (ρ = 0.24, 95% CI 0.09-0.39; P =.003). We found that age, high sensitivity C-reactive protein, being male, and systolic blood pressure were positively associated with NT-pro-BNP levels whereas body mass index, low-density/high-density lipoprotein ratio, and Homeostasis Model of Assessment-Insulin Resistance were negatively associated (all P ≤.02).

Conclusions: In this population-based study in a high-altitude setting, neither NT-pro-BNP levels nor echocardiography-derived PASP were associated with chronic exposure to biomass fuel smoke.

Original languageEnglish (US)
Pages (from-to)731-738
Number of pages8
JournalAmerican heart journal
Volume168
Issue number5
DOIs
StatePublished - Nov 1 2014

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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