Lack of association between augmentation mammoplasty and systemic sclerosis (scleroderma)

Marc C. Hochberg, Donna L. Perlmutter, Thomas A. Medsger, Katherine Nguyen, Virginia Steen, Michael H. Weisman, Barbara White, Fredrick Wigley

Research output: Contribution to journalArticle

Abstract

Objective. To examine the possible association between augmentation mammoplasty and systemic sclerosis (SSc; scleroderma). Methods. Eight hundred thirty-seven women with a clinical diagnosis of SSc, recruited as a volunteer sample from 3 university-based, tertiary care scleroderma clinical research centers, and 2,507 race-matched local control women, recruited by the technique of random-digit-dialing and frequency-matched on age, completed a questionnaire providing data on history of augmentation mammoplasty, including possible complications of the procedure. The odds ratio (OR) and 95 percent confidence interval (95% CI) for the association of augmentation mammoplasty with SSc were estimated by multivariate logistic regression analysis with adjustment for age, race and center, and by conditional logistic regression analysis with adjustment for age. Results. Eleven (1.31%) of the 837 cases reported a history of augmentation mammoplasty prior to diagnosis of SSc, compared with 31 (1.24%) of the 2,507 controls. The adjusted OR from the unmatched analysis was 1.07 (95% CI 0.53-2.13), while that from the matched analysis was 1.11 (95% CI 0.55-2.24). Conclusion. These results fail to demonstrate a significant association between augmentation mammoplasty and SSc, and are consistent with those reported from other epidemiologic studies.

Original languageEnglish (US)
Pages (from-to)1125-1131
Number of pages7
JournalArthritis and Rheumatism
Volume39
Issue number7
DOIs
StatePublished - Jul 1996

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ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

Hochberg, M. C., Perlmutter, D. L., Medsger, T. A., Nguyen, K., Steen, V., Weisman, M. H., White, B., & Wigley, F. (1996). Lack of association between augmentation mammoplasty and systemic sclerosis (scleroderma). Arthritis and Rheumatism, 39(7), 1125-1131. https://doi.org/10.1002/art.1780390708