Lack of association between anti-V3 loop antibodies and perinatal transmission of HIV-1 in Kampala, Uganda

H. Epstein, L. Guay, D. Hom, F. Mmiro, C. Ndugwa, L. Marum, K. Olness, E. Piwowar, P. Kataaba, J. Baenziger, J. B. Jackson

Research output: Contribution to journalArticle

Abstract

This study evaluated the association between reactivity of maternal antibody to human immunodeficiency virus type 1 (HIV-1) V3 loop peptides and perinatal transmission in Uganda. Plasma from 40 HIV-1-infected mothers (20 transmitting and 20 non-transmitting mothers) and 31 uninfected mothers in Uganda were tested for reactivity and antibody titer to synthetic peptides representing V3 loop sequences from HIV-1 strains MN, SF2, LAI, ZR6, and CM235 and consensus peptides CA, CB, and CD. No significant differences were found between 20 transmitting mothers and 20 nontransmitting mothers in terms of percent reactivity or titer of antibody to any of the V3 loop peptides tested. Use of a multivariable logistic model to adjust for beta-2 microglobulin level as a confounding variable of stage of infection did not help demonstrate an association except possibly for the ZR6 peptide. These data suggest that neither reactivity nor maternal antibody titer to V3 loop peptides are protective against perinatal transmission of HIV-1 in Uganda.

Original languageEnglish (US)
Pages (from-to)350-356
Number of pages7
JournalPediatric AIDS and HIV Infection
Volume5
Issue number6
StatePublished - 1994
Externally publishedYes

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Uganda
HIV-1
Peptides
Antibodies
Mothers
beta 2-Microglobulin
Confounding Factors (Epidemiology)
Logistic Models
Infection

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Epstein, H., Guay, L., Hom, D., Mmiro, F., Ndugwa, C., Marum, L., ... Jackson, J. B. (1994). Lack of association between anti-V3 loop antibodies and perinatal transmission of HIV-1 in Kampala, Uganda. Pediatric AIDS and HIV Infection, 5(6), 350-356.

Lack of association between anti-V3 loop antibodies and perinatal transmission of HIV-1 in Kampala, Uganda. / Epstein, H.; Guay, L.; Hom, D.; Mmiro, F.; Ndugwa, C.; Marum, L.; Olness, K.; Piwowar, E.; Kataaba, P.; Baenziger, J.; Jackson, J. B.

In: Pediatric AIDS and HIV Infection, Vol. 5, No. 6, 1994, p. 350-356.

Research output: Contribution to journalArticle

Epstein, H, Guay, L, Hom, D, Mmiro, F, Ndugwa, C, Marum, L, Olness, K, Piwowar, E, Kataaba, P, Baenziger, J & Jackson, JB 1994, 'Lack of association between anti-V3 loop antibodies and perinatal transmission of HIV-1 in Kampala, Uganda', Pediatric AIDS and HIV Infection, vol. 5, no. 6, pp. 350-356.
Epstein, H. ; Guay, L. ; Hom, D. ; Mmiro, F. ; Ndugwa, C. ; Marum, L. ; Olness, K. ; Piwowar, E. ; Kataaba, P. ; Baenziger, J. ; Jackson, J. B. / Lack of association between anti-V3 loop antibodies and perinatal transmission of HIV-1 in Kampala, Uganda. In: Pediatric AIDS and HIV Infection. 1994 ; Vol. 5, No. 6. pp. 350-356.
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