Lack of ability of ciprofloxacin-rifampin prophylaxis to decrease infection-related morbidity in neutropenic patients given cytotoxic therapy and peripheral blood stem cell transplants

Manuel Hidalgo, Javier Hornedo, Carlos Lumbreras, José Manuel Trigo, Carlos Gómez, Sofia Perea, Ana Ruiz, Ricardo Hitt, Hernán Cortés-Funes

Research output: Contribution to journalArticle

Abstract

We compared ciprofloxacin alone with ciprofloxacin plus rifampin (C + R) as a prophylactic antibacterial regimen for 40 patients with solid tumors treated with high-dose chemotherapy and autologous stem cell transplantation support. No differences were found between groups in the time elapsed to the onset of fever, incidence of febrile episodes, amphotericin B use, and length of hospital stay. However, C + R combination prophylaxis significantly reduced the incidence of gram-positive bacteremia (five versus zero episodes) but was associated with a higher incidence of drug-related side effects.

Original languageEnglish (US)
Pages (from-to)1175-1177
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume41
Issue number5
StatePublished - 1997
Externally publishedYes

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Rifampin
Ciprofloxacin
Morbidity
Transplants
Length of Stay
Incidence
Fever
Infection
Stem Cell Transplantation
Amphotericin B
Bacteremia
Drug-Related Side Effects and Adverse Reactions
Therapeutics
Drug Therapy
Peripheral Blood Stem Cells
Neoplasms

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Lack of ability of ciprofloxacin-rifampin prophylaxis to decrease infection-related morbidity in neutropenic patients given cytotoxic therapy and peripheral blood stem cell transplants. / Hidalgo, Manuel; Hornedo, Javier; Lumbreras, Carlos; Trigo, José Manuel; Gómez, Carlos; Perea, Sofia; Ruiz, Ana; Hitt, Ricardo; Cortés-Funes, Hernán.

In: Antimicrobial Agents and Chemotherapy, Vol. 41, No. 5, 1997, p. 1175-1177.

Research output: Contribution to journalArticle

Hidalgo, M, Hornedo, J, Lumbreras, C, Trigo, JM, Gómez, C, Perea, S, Ruiz, A, Hitt, R & Cortés-Funes, H 1997, 'Lack of ability of ciprofloxacin-rifampin prophylaxis to decrease infection-related morbidity in neutropenic patients given cytotoxic therapy and peripheral blood stem cell transplants', Antimicrobial Agents and Chemotherapy, vol. 41, no. 5, pp. 1175-1177.
Hidalgo, Manuel ; Hornedo, Javier ; Lumbreras, Carlos ; Trigo, José Manuel ; Gómez, Carlos ; Perea, Sofia ; Ruiz, Ana ; Hitt, Ricardo ; Cortés-Funes, Hernán. / Lack of ability of ciprofloxacin-rifampin prophylaxis to decrease infection-related morbidity in neutropenic patients given cytotoxic therapy and peripheral blood stem cell transplants. In: Antimicrobial Agents and Chemotherapy. 1997 ; Vol. 41, No. 5. pp. 1175-1177.
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