Lack of ability of ciprofloxacin-rifampin prophylaxis to decrease infection-related morbidity in neutropenic patients given cytotoxic therapy and peripheral blood stem cell transplants

Manuel Hidalgo, Javier Hornedo, Carlos Lumbreras, José Manuel Trigo, Carlos Gómez, Sofia Perea, Ana Ruiz, Ricardo Hitt, Hernán Cortés-Funes

Research output: Contribution to journalArticlepeer-review

Abstract

We compared ciprofloxacin alone with ciprofloxacin plus rifampin (C + R) as a prophylactic antibacterial regimen for 40 patients with solid tumors treated with high-dose chemotherapy and autologous stem cell transplantation support. No differences were found between groups in the time elapsed to the onset of fever, incidence of febrile episodes, amphotericin B use, and length of hospital stay. However, C + R combination prophylaxis significantly reduced the incidence of gram-positive bacteremia (five versus zero episodes) but was associated with a higher incidence of drug-related side effects.

Original languageEnglish (US)
Pages (from-to)1175-1177
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume41
Issue number5
DOIs
StatePublished - May 1997

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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