TY - JOUR
T1 - Lack of a relation between serum 25-hydroxyvitamin D concentrations and asthma in adolescents
AU - Gergen, Peter J.
AU - Teach, Stephen J.
AU - Mitchell, Herman E.
AU - Freishtat, Robert F.
AU - Calatroni, Agustin
AU - Matsui, Elizabeth
AU - Kattan, Meyer
AU - Bloomberg, Gordon R.
AU - Liu, Andrew H.
AU - Kercsmar, Carolyn
AU - O'Connor, George
AU - Pongracic, Jacqueline
AU - Rivera-Sanchez, Yadira
AU - Morgan, Wayne J.
AU - Sorkness, Christine A.
AU - Binkley, Neil
AU - Busse, William
PY - 2013/6/1
Y1 - 2013/6/1
N2 - Background: Decreased 25-hydroxyvitamin D [25(OH)D] concentrations have been associated with an increased prevalence and severity of asthma and a lower response to inhaled corticosteroids. Objective: The objective was to determine the association between serum 25(OH)D concentrations and asthma prevalence, severity, and response to asthma treatment. Design: Secondary analyses were conducted in 2 samples of adolescents 12-20 y of age: 1) NHANES 2001-2006 (n = 6487), a cross-sectional nationally representative sample of the US population, and 2) a cohort of inner-city adolescents with asthma managed prospectively for 46 wk with guidelines-based therapy in the Asthma Control Evaluation (ACE; n = 226) trial. Results: Mean (±SD) serum 25(OH)D concentrations in the NHANES and ACE samples were lower in African Americans than in non-African Americans (NHANES: 14.9 ± 6.5 compared with 23.0 ± 8.4 ng/mL, P <0.0001; ACE: 11.2 ± 6.9 compared with 15.8 ± 7.1 ng/mL, P <0.0001). In the NHANES sample, mean concentrations did not differ between participants without and with asthma (African Americans: 14.9 ± 6.4 compared with 15.0 ± 6.6 ng/mL, respectively, P = 0.87; non-African Americans: 23.0 ± 8.5 compared with 23.6 ± 8.2 ng/mL, respectively, P = 0.16). In the ACE models that used either a predefined cutoff (
AB - Background: Decreased 25-hydroxyvitamin D [25(OH)D] concentrations have been associated with an increased prevalence and severity of asthma and a lower response to inhaled corticosteroids. Objective: The objective was to determine the association between serum 25(OH)D concentrations and asthma prevalence, severity, and response to asthma treatment. Design: Secondary analyses were conducted in 2 samples of adolescents 12-20 y of age: 1) NHANES 2001-2006 (n = 6487), a cross-sectional nationally representative sample of the US population, and 2) a cohort of inner-city adolescents with asthma managed prospectively for 46 wk with guidelines-based therapy in the Asthma Control Evaluation (ACE; n = 226) trial. Results: Mean (±SD) serum 25(OH)D concentrations in the NHANES and ACE samples were lower in African Americans than in non-African Americans (NHANES: 14.9 ± 6.5 compared with 23.0 ± 8.4 ng/mL, P <0.0001; ACE: 11.2 ± 6.9 compared with 15.8 ± 7.1 ng/mL, P <0.0001). In the NHANES sample, mean concentrations did not differ between participants without and with asthma (African Americans: 14.9 ± 6.4 compared with 15.0 ± 6.6 ng/mL, respectively, P = 0.87; non-African Americans: 23.0 ± 8.5 compared with 23.6 ± 8.2 ng/mL, respectively, P = 0.16). In the ACE models that used either a predefined cutoff (
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U2 - 10.3945/ajcn.112.046961
DO - 10.3945/ajcn.112.046961
M3 - Article
C2 - 23595876
AN - SCOPUS:84878422234
SN - 0002-9165
VL - 97
SP - 1228
EP - 1234
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
IS - 6
ER -