TY - JOUR
T1 - Laboratory values for children with newly diagnosed inflammatory bowel disease
AU - Mack, David R.
AU - Langton, Christine
AU - Markowitz, James
AU - Leleiko, Neal
AU - Griffiths, Anne
AU - Bousvaros, Athos
AU - Evans, Jonathan
AU - Kugathasan, Subra
AU - Otley, Anthony
AU - Pfefferkorn, Mariann
AU - Rosh, Joel
AU - Mezoff, Adam
AU - Moyer, Susan
AU - Oliva-Hemker, Maria
AU - Rothbaum, Robert
AU - Wyllie, Robert
AU - DelRosario, J. Fernando
AU - Keljo, David
AU - Lerer, Trudy
AU - Hyams, Jeffrey
PY - 2007/6
Y1 - 2007/6
N2 - OBJECTIVE. The goal was to determine how often common laboratory tests yield normal results at the time of diagnosis for children with inflammatory bowel disease. METHODS. Data were obtained from a registry of children with newly diagnosed inflammatory bowel disease who were enrolled prospectively in 18 US/Canadian centers. Laboratory values investigated included hemoglobin level, platelet count, albumin level, and erythrocyte sedimentation rate. Disease severity was categorized by physician global assessment. RESULTS. A total of 526 children (mean age: 11.6 years; 58% male; 392 with Crohn disease and 134 with ulcerative colitis) were studied. All 4 values were normal for 21% of patients with mild Crohn disease and 54% with mild ulcerative colitis. In contrast, only 3.8% of children with moderate/severe Crohn disease and 4.3% with moderate/severe ulcerative colitis had normal results for all 4 tests. The erythrocyte sedimentation rate was least likely to be normal; overall, 26% of patients with inflammatory bowel disease had a normal erythrocyte sedimentation rate, including 18% with moderate/severe disease. Hemoglobin levels were normal for 32%, platelet counts for 50%, and albumin levels for 60%. There was no clear association between Crohn disease location and either severity or number of normal laboratory values. In contrast, there were direct correlations between ulcerative colitis disease severity and both the extent of bowel inflammation and the number of abnormal laboratory tests. CONCLUSION. The presence of normal screening laboratory studies should not dissuade clinicians from considering a diagnosis of inflammatory bowel disease.
AB - OBJECTIVE. The goal was to determine how often common laboratory tests yield normal results at the time of diagnosis for children with inflammatory bowel disease. METHODS. Data were obtained from a registry of children with newly diagnosed inflammatory bowel disease who were enrolled prospectively in 18 US/Canadian centers. Laboratory values investigated included hemoglobin level, platelet count, albumin level, and erythrocyte sedimentation rate. Disease severity was categorized by physician global assessment. RESULTS. A total of 526 children (mean age: 11.6 years; 58% male; 392 with Crohn disease and 134 with ulcerative colitis) were studied. All 4 values were normal for 21% of patients with mild Crohn disease and 54% with mild ulcerative colitis. In contrast, only 3.8% of children with moderate/severe Crohn disease and 4.3% with moderate/severe ulcerative colitis had normal results for all 4 tests. The erythrocyte sedimentation rate was least likely to be normal; overall, 26% of patients with inflammatory bowel disease had a normal erythrocyte sedimentation rate, including 18% with moderate/severe disease. Hemoglobin levels were normal for 32%, platelet counts for 50%, and albumin levels for 60%. There was no clear association between Crohn disease location and either severity or number of normal laboratory values. In contrast, there were direct correlations between ulcerative colitis disease severity and both the extent of bowel inflammation and the number of abnormal laboratory tests. CONCLUSION. The presence of normal screening laboratory studies should not dissuade clinicians from considering a diagnosis of inflammatory bowel disease.
KW - Albumin
KW - Crohn disease
KW - Erythrocyte sedimentation rate
KW - Hemoglobin
KW - Platelets
KW - Ulcerative colitis
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U2 - 10.1542/peds.2006-1865
DO - 10.1542/peds.2006-1865
M3 - Article
C2 - 17545378
AN - SCOPUS:34249900973
SN - 0031-4005
VL - 119
SP - 1113
EP - 1119
JO - Pediatrics
JF - Pediatrics
IS - 6
ER -