Laboratory testing in peripheral nerve disease

J. W. Griffin, S. T. Hsieh, Justin Charles McArthur, David Cornblath

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Abstract

Selecting appropriate laboratory tests in diagnosing peripheral neuropathies is important because it increases the yield of correct diagnoses and is cost effective. A large number of tests are available. This article provides a guide to selecting appropriate tests and reviews the clinical situations that suggest specific tests. Electrodiagnostic testing is valuable in almost all patients with peripheral neuropathy. Quantitative sensory testing adds additional information and is especially useful in patients with small fiber neuropathy. On occasion, routine blood tests may discover metabolic disorders causing a patient's neurologic disorder. A number of antibody assays for neuropathies are available commercially, with the most useful being antiMAG, anti-GM1, anti-GQ1b, anti-Hu, and anticalcium channel antibodies, but only in very select situations and not as 'screening studies.' The role of cutaneous nerve and skin biopsies in selected disorders is discussed.

Original languageEnglish (US)
Pages (from-to)119-133
Number of pages15
JournalNeurologic Clinics
Volume14
Issue number1
DOIs
Publication statusPublished - 1996

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ASJC Scopus subject areas

  • Clinical Neurology

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