Laboratory parameters in patients randomized in the stop study and their modification by transfusion

A. Kutlar, J. Harbin, B. Jackson, L. Holley, D. Gallagher, B. Clair, D. Brambilla, R. Adams, V. McKie, L. Hsu, B. Files, E. Vichinsky, C. Pegelow, M. Abboud, G. Woods, N. Olivieri, C. Driscoll, S. Miller, W. Wang, S. PiomelliC. Scher, B. Berman

Research output: Contribution to journalArticlepeer-review

Abstract

The STOP study was the first randomized trial of primary stroke prevention in sickle cell disease (Hb SS). 130 Hb SS children, age 2-16, at risk for stroke by Transcranial Doppier (TCD) were randomized to standard care (STC) (n=67) or transfusion (Tx)(n=63). There were no significant clinical or hématologie differences between the two groups except for a lower Hb (7.2 vs 7.6 g/dl, p=.001 ) and Hct (20.4 vs 21.7%, p=.002) in the Tx arm. Tx arm patients (transfused every 3-4 weeks to maintain Hb S

Original languageEnglish (US)
JournalBlood
Volume96
Issue number11 PART II
StatePublished - 2000
Externally publishedYes

ASJC Scopus subject areas

  • Hematology

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