Laboratory detection of sepsis: Biomarkers and molecular approaches.

Stefan Riedel, Karen C. Carroll

Research output: Contribution to journalReview articlepeer-review

Abstract

Sepsis, severe sepsis, and septic shock cause significant morbidity and mortality worldwide. Rapid diagnosis and therapeutic interventions are desirable to improve the overall mortality in patients with sepsis. However, gold standard laboratory diagnostic methods for sepsis, pose a significant challenge to rapid diagnosis of sepsis by physicians and laboratories. This article discusses the usefulness and potential of biomarkers and molecular test methods for a more rapid clinical and laboratory diagnosis of sepsis. Because new technologies are quickly emerging, physicians and laboratories must appreciate the key factors and characteristics that affect the clinical usefulness and diagnostic accuracy of these test methodologies.

Original languageEnglish (US)
Pages (from-to)413-437
Number of pages25
JournalClinics in laboratory medicine
Volume33
Issue number3
DOIs
StatePublished - Sep 1 2013

Keywords

  • Bacteremia
  • Biomarkers
  • C-reactive protein
  • Molecular diagnostics
  • Nucleic acid amplification testing
  • Procalcitonin
  • Sepsis

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

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