Label-free biosensing with high sensitivity in dual-core microstructured polymer optical fibers

Christos Markos, Wu Yuan, Kyriakos Vlachos, Graham E. Town, Ole Ban

Research output: Contribution to journalArticlepeer-review

Abstract

We present experimentally feasible designs of a dual-core microstructured polymer optical fiber (mPOF), which can act as a highly sensitive, label-free, and selective biosensor. An immobilized antigen sensing layer on the walls of the holes in the mPOF provides the ability to selectively capture antibody biomolecules. The change of the layer thickness of biomolecules can then be detected as a change in the coupling length between the two cores. We compare mPOF structures with 1, 2, and 3 air-holes between the solid cores and show that the sensitivity increases with increasing distance between the cores. Numerical calculations indicate a record sensitivity up to 20 nm/nm (defined as the shift in the resonance wavelength per nm biolayer) at visible wavelengths, where the mPOF has low loss.

Original languageEnglish (US)
Pages (from-to)7790-7798
Number of pages9
JournalOptics Express
Volume19
Issue number8
DOIs
StatePublished - Apr 11 2011
Externally publishedYes

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

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