Laam dose comparison: A clinical trial

R. E. Johnson, T. Eissenberg, E. C. Strain, S. L. Walsh, R. K. Brooner, I. A. Liebson, M. L. Stitzer, G. E. Bigelow

Research output: Contribution to journalArticle

Abstract

LAAM is the most recently approved pharmacotherapy for opioid dependence. To date, there have been no clinical trials assessing the dose effectiveness of LAAM. Purpose: To assess the effectiveness of three LAAM dose conditions. Methods: Opioid-dependent subjects (N=180) were stratified and randomly assigned to a 29 wk double-blind clinical trial comparing three, thrice-weekly (M/W/F) LAAM dose conditions. Subjects in the low (N=62), medium (N=59), and high (N=59) dose conditions received 25/25/35, 50/50/70, and 100/100/140 mg, respectively. Primary outcome measures assessed through the maintenance period (wk 17) were: 1) overall percent negative (a) opioid and (b) cocaine urine specimens, 2) percent of subjects with 12 consecutive opioid negative urine specimens, and 3) treatment retention. Results: Significant differences were observed across conditions for measures 1a and 2. Overall urine specimens negative for opioids were, 23.1%, 32.4%, and 40.8% and the percent of patients able to provide 12 consecutive opioid negative urine specimens were 11%, 20%, and 32% for the low, medium, and high dose conditions, respectively. There were no differences between conditions for measures 1b and 3. Conclusion: The effectiveness of LAAM treatment on rates of opioid negative urine specimens increases with increasing LAAM dose.

Original languageEnglish (US)
Number of pages1
JournalClinical pharmacology and therapeutics
Volume61
Issue number2
StatePublished - Dec 1 1997

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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