L-PGDS (betatrace protein) inhibits astrocyte proliferation and mitochondrial ATP production in vitro

Xiaorong Xin, Andreas Huber, Peter Meyer, Josef Flammer, Albert Neutzner, Neil R. Miller, Hanspeter E. Killer

Research output: Contribution to journalArticlepeer-review

Abstract

L-PGDS is the most abundant protein present in the cerebrospinal fluid (CSF). Although CSF was believed to be homogenous in content, a previous study has showed that a marked concentration gradient of L-PGDS exists between the spinal CSF and the CSF in the subarachnoid space of patients with optic nerve disease (papilledema and normaltension glaucoma). Astrocytes play a critical role in maintaining the integrity of axon function in the central nervous system and specifically in the optic nerve, and we therefore investigated the biochemical effects of L-PGDS on the proliferation of astrocytes and on the production of adenosine triphosphate (ATP) by astrocyte mitochondria. We found an inhibitory effect of L-PGDS on both proliferation of astrocytes and production of astrocyte ATP. The concentrations that inhibited astrocyte proliferation and ATP production were in the range measured in patients with idiopathic intracranial hypertension and in patients with normal-tension glaucoma. As the CSF is in contact with axons and mitochondria of the optic nerve (Bristow et al. Archives of Ophthalmology, 120, 791-796, 2002), we postulate that a change in the concentration of CSF protein such as L-PGDS could exercise a harmful effect on these structures.

Original languageEnglish (US)
Pages (from-to)366-371
Number of pages6
JournalJournal of Molecular Neuroscience
Volume39
Issue number3
DOIs
StatePublished - Nov 2009

Keywords

  • Astrocytes
  • Betatrace protein
  • Glaucoma
  • L-PGDS
  • Mitochondria
  • Optic nerve

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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