L- and M-cone driven ERGs are differently altered in Best's macular dystrophy

Hendrik P.N. Scholl, Jan Kremers, Eckart Apfelstedt-Sylla, Eberhart Zrenner

Research output: Contribution to journalArticlepeer-review

Abstract

To study the L- and M-cone pathways and their interactions in patients with Best's macular dystrophy (BMD), ERG response thresholds were measured to stimuli which modulated exclusively the L- or the M-cones, or both in various combinations. The ERG threshold data could be described with a vector addition model. Compared with normals, BMD patients showed generally larger amplitudes of the L-cone driven ERGs. However, the M-cone driven ERGs were similar in amplitude but significantly phase advanced. The data confirm our previous observations that L- and M-cone pathways can be affected differently by retinal degeneration, despite their large physiological and biochemical similarities. Copyright (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)3159-3168
Number of pages10
JournalVision Research
Volume40
Issue number22
DOIs
StatePublished - Oct 2000

Keywords

  • Best's macular dystrophy
  • Cone weighting
  • Electroretinography (ERG)
  • L-cones
  • M-cones

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

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