L- and M-cone driven ERGs are differently altered in Best's macular dystrophy

Hendrik P.N. Scholl; Jan Kremers; Eckart Apfelstedt-Sylla; Eberhart Zrenner

doi:10.1016/S0042-6989(00)00160-7

L- and M-cone driven ERGs are differently altered in Best's macular dystrophy

Hendrik P.N. Scholl, Jan Kremers, Eckart Apfelstedt-Sylla, Eberhart Zrenner

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

To study the L- and M-cone pathways and their interactions in patients with Best's macular dystrophy (BMD), ERG response thresholds were measured to stimuli which modulated exclusively the L- or the M-cones, or both in various combinations. The ERG threshold data could be described with a vector addition model. Compared with normals, BMD patients showed generally larger amplitudes of the L-cone driven ERGs. However, the M-cone driven ERGs were similar in amplitude but significantly phase advanced. The data confirm our previous observations that L- and M-cone pathways can be affected differently by retinal degeneration, despite their large physiological and biochemical similarities. Copyright (C) 2000 Elsevier Science Ltd.

Original language	English (US)
Pages (from-to)	3159-3168
Number of pages	10
Journal	Vision Research
Volume	40
Issue number	22
DOIs	https://doi.org/10.1016/S0042-6989(00)00160-7
State	Published - Oct 2000
Externally published	Yes

Keywords

Best's macular dystrophy
Cone weighting
Electroretinography (ERG)
L-cones
M-cones

ASJC Scopus subject areas

Ophthalmology
Sensory Systems

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10.1016/S0042-6989(00)00160-7

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title = "L- and M-cone driven ERGs are differently altered in Best's macular dystrophy",

abstract = "To study the L- and M-cone pathways and their interactions in patients with Best's macular dystrophy (BMD), ERG response thresholds were measured to stimuli which modulated exclusively the L- or the M-cones, or both in various combinations. The ERG threshold data could be described with a vector addition model. Compared with normals, BMD patients showed generally larger amplitudes of the L-cone driven ERGs. However, the M-cone driven ERGs were similar in amplitude but significantly phase advanced. The data confirm our previous observations that L- and M-cone pathways can be affected differently by retinal degeneration, despite their large physiological and biochemical similarities. Copyright (C) 2000 Elsevier Science Ltd.",

keywords = "Best's macular dystrophy, Cone weighting, Electroretinography (ERG), L-cones, M-cones",

author = "Scholl, {Hendrik P.N.} and Jan Kremers and Eckart Apfelstedt-Sylla and Eberhart Zrenner",

note = "Funding Information: We thank R. Vonthein for statistical analysis; K. G{\"o}tz, C. Reichl, J. Isensee, and E. Burkhardt for technical assistance; and D. Besch for clinical work-up contributions. This work was supported by fort{\"u}ne-Grant 707-0-0 (T{\"u}bingen, Germany) to HS and JK; DFG (German Research Council) SFB 430/C2 to EAS and EZ; SFB 430/C3 and a DFG Heisenberg fellowship to JK.",

year = "2000",

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doi = "10.1016/S0042-6989(00)00160-7",

language = "English (US)",

volume = "40",

pages = "3159--3168",

journal = "Vision Research",

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T1 - L- and M-cone driven ERGs are differently altered in Best's macular dystrophy

AU - Scholl, Hendrik P.N.

AU - Kremers, Jan

AU - Apfelstedt-Sylla, Eckart

AU - Zrenner, Eberhart

N1 - Funding Information: We thank R. Vonthein for statistical analysis; K. Götz, C. Reichl, J. Isensee, and E. Burkhardt for technical assistance; and D. Besch for clinical work-up contributions. This work was supported by fortüne-Grant 707-0-0 (Tübingen, Germany) to HS and JK; DFG (German Research Council) SFB 430/C2 to EAS and EZ; SFB 430/C3 and a DFG Heisenberg fellowship to JK.

PY - 2000/10

Y1 - 2000/10

N2 - To study the L- and M-cone pathways and their interactions in patients with Best's macular dystrophy (BMD), ERG response thresholds were measured to stimuli which modulated exclusively the L- or the M-cones, or both in various combinations. The ERG threshold data could be described with a vector addition model. Compared with normals, BMD patients showed generally larger amplitudes of the L-cone driven ERGs. However, the M-cone driven ERGs were similar in amplitude but significantly phase advanced. The data confirm our previous observations that L- and M-cone pathways can be affected differently by retinal degeneration, despite their large physiological and biochemical similarities. Copyright (C) 2000 Elsevier Science Ltd.

AB - To study the L- and M-cone pathways and their interactions in patients with Best's macular dystrophy (BMD), ERG response thresholds were measured to stimuli which modulated exclusively the L- or the M-cones, or both in various combinations. The ERG threshold data could be described with a vector addition model. Compared with normals, BMD patients showed generally larger amplitudes of the L-cone driven ERGs. However, the M-cone driven ERGs were similar in amplitude but significantly phase advanced. The data confirm our previous observations that L- and M-cone pathways can be affected differently by retinal degeneration, despite their large physiological and biochemical similarities. Copyright (C) 2000 Elsevier Science Ltd.

KW - Best's macular dystrophy

KW - Cone weighting

KW - Electroretinography (ERG)

KW - L-cones

KW - M-cones

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ER -

L- and M-cone driven ERGs are differently altered in Best's macular dystrophy

Abstract

Keywords

ASJC Scopus subject areas

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