Abstract
Although Krüppel-like factors (KLFs) have been the subject of extensive biological investigation, the role of this family of transcription factors in the biology and pathophysiology of the vascular endothelium is just becoming apparent. Most investigative efforts thus far have focused on KLF2, its contribution to the endothelial vasoprotective phenotype, and its possible impact on atherogenesis. This chapter reflects on the current state of the field and highlights evolving areas where KLFs are emerging as important regulators of endothelial function.
Original language | English (US) |
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Title of host publication | The Biology of Krüppel-like Factors |
Publisher | Springer Japan |
Pages | 173-184 |
Number of pages | 12 |
ISBN (Print) | 9784431877745 |
DOIs | |
State | Published - 2009 |
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology