Known glioma risk loci are associated with glioma with a family history of brain tumours - A case-control gene association study

Beatrice Melin, Anna M. Dahlin, Ulrika Andersson, Zhaoming Wang, Roger Henriksson, Göran Hallmans, Melissa L. Bondy, Christoffer Johansen, Maria Feychting, Anders Ahlbom, Cari M. Kitahara, Sophia S. Wang, Avima M. Ruder, Tania Carreõn, Mary Ann Butler, Peter D. Inskip, Mark Purdue, Ann W. Hsing, Leah Mechanic, Elizabeth GillandersMeredith Yeager, Martha Linet, Stephen J. Chanock, Patricia Hartge, Preetha Rajaraman

Research output: Contribution to journalArticle

Abstract

Familial cancer can be used to leverage genetic association studies. Recent genome-wide association studies have reported independent associations between seven single nucleotide polymorphisms (SNPs) and risk of glioma. The aim of this study was to investigate whether glioma cases with a positive family history of brain tumours, defined as having at least one first- or second-degree relative with a history of brain tumour, are associated with known glioma risk loci. One thousand four hundred and thirty-one glioma cases and 2,868 cancer-free controls were identified from four case-control studies and two prospective cohorts from USA, Sweden and Denmark and genotyped for seven SNPs previously reported to be associated with glioma risk in case-control designed studies. Odds ratios were calculated by unconditional logistic regression. In analyses including glioma cases with a family history of brain tumours (n = 104) and control subjects free of glioma at baseline, three of seven SNPs were associated with glioma risk: rs2736100 (5p15.33, TERT), rs4977756 (9p21.3, CDKN2A-CDKN2B) and rs6010620 (20q13.33, RTEL1). After Bonferroni correction for multiple comparisons, only one marker was statistically significantly associated with glioma risk, rs6010620 (ORtrend for the minor (A) allele, 0.39; 95% CI: 0.25-0.61; Bonferroni adjusted ptrend, 1.7 × 10-4). In conclusion, as previously shown for glioma regardless of family history of brain tumours, rs6010620 (RTEL1) was associated with an increased risk of glioma when restricting to cases with family history of brain tumours. These findings require confirmation in further studies with a larger number of glioma cases with a family history of brain tumours. What's new? Genomic research has recently identified seven single-nucleotide polymorphisms (SNPs) that are associated with an increased risk of glioma. In this study, the authors report that the association between one of these SNPs (rs6010620 in the RTEL1 gene) and glioma is stronger in people with a family history of brain tumor compared to those without such a history. This correlation may help to define genetic factors that increase the risk of developing this form of cancer.

Original languageEnglish (US)
Pages (from-to)2464-2468
Number of pages5
JournalInternational Journal of Cancer
Volume132
Issue number10
DOIs
Publication statusPublished - May 15 2013
Externally publishedYes

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Keywords

  • brain tumours
  • genome-wide association study
  • Glioma
  • single nucleotide polymorphism

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Melin, B., Dahlin, A. M., Andersson, U., Wang, Z., Henriksson, R., Hallmans, G., ... Rajaraman, P. (2013). Known glioma risk loci are associated with glioma with a family history of brain tumours - A case-control gene association study. International Journal of Cancer, 132(10), 2464-2468. https://doi.org/10.1002/ijc.27922