Knocking Out Non-muscle Myosin II in Retinal Ganglion Cells Promotes Long-Distance Optic Nerve Regeneration

Xue Wei Wang; Shu Guang Yang; Chi Zhang; Ming Wen Hu; Jiang Qian; Jin Jin Ma; Yingchi Zhang; Bin Bin Yang; Yi Lan Weng; Guo Li Ming; Anish R. Kosanam; Saijilafu; Feng Quan Zhou

doi:10.1016/j.celrep.2020.107537

Knocking Out Non-muscle Myosin II in Retinal Ganglion Cells Promotes Long-Distance Optic Nerve Regeneration

Xue Wei Wang, Shu Guang Yang, Chi Zhang, Ming Wen Hu, Jiang Qian, Jin Jin Ma, Yingchi Zhang, Bin Bin Yang, Yi Lan Weng, Guo Li Ming, Anish R. Kosanam, Saijilafu, Feng Quan Zhou

School of Medicine

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Although modulating the neuronal cytoskeleton has been deemed a promising approach to enhance mammalian axon regeneration, only a few studies have shown convincing results, especially in the central nervous system. Wang et al. demonstrate that the deletion of non-muscle myosin II sufficiently induces significant mammalian CNS axon regeneration in vivo.

Original language	English (US)
Article number	107537
Journal	Cell Reports
Volume	31
Issue number	3
DOIs	https://doi.org/10.1016/j.celrep.2020.107537
State	Published - Apr 21 2020

Keywords

Lin28
axon regeneration
cytoskeleton
growth cone
non-muscle myosin II
optic nerve regeneration
post-injury treatment
retinal ganglion cells
retraction bulb

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1016/j.celrep.2020.107537

Cite this

@article{24ac12f508da4996b759aa770402bb44,

title = "Knocking Out Non-muscle Myosin II in Retinal Ganglion Cells Promotes Long-Distance Optic Nerve Regeneration",

abstract = "Although modulating the neuronal cytoskeleton has been deemed a promising approach to enhance mammalian axon regeneration, only a few studies have shown convincing results, especially in the central nervous system. Wang et al. demonstrate that the deletion of non-muscle myosin II sufficiently induces significant mammalian CNS axon regeneration in vivo.",

keywords = "Lin28, axon regeneration, cytoskeleton, growth cone, non-muscle myosin II, optic nerve regeneration, post-injury treatment, retinal ganglion cells, retraction bulb",

author = "Wang, {Xue Wei} and Yang, {Shu Guang} and Chi Zhang and Hu, {Ming Wen} and Jiang Qian and Ma, {Jin Jin} and Yingchi Zhang and Yang, {Bin Bin} and Weng, {Yi Lan} and Ming, {Guo Li} and Kosanam, {Anish R.} and Saijilafu and Zhou, {Feng Quan}",

note = "Publisher Copyright: {\textcopyright} 2020 The Author(s)",

year = "2020",

month = apr,

day = "21",

doi = "10.1016/j.celrep.2020.107537",

language = "English (US)",

volume = "31",

journal = "Cell Reports",

issn = "2211-1247",

publisher = "Cell Press",

number = "3",

}

TY - JOUR

T1 - Knocking Out Non-muscle Myosin II in Retinal Ganglion Cells Promotes Long-Distance Optic Nerve Regeneration

AU - Wang, Xue Wei

AU - Yang, Shu Guang

AU - Zhang, Chi

AU - Hu, Ming Wen

AU - Qian, Jiang

AU - Ma, Jin Jin

AU - Zhang, Yingchi

AU - Yang, Bin Bin

AU - Weng, Yi Lan

AU - Ming, Guo Li

AU - Kosanam, Anish R.

AU - Saijilafu,

AU - Zhou, Feng Quan

PY - 2020/4/21

Y1 - 2020/4/21

N2 - Although modulating the neuronal cytoskeleton has been deemed a promising approach to enhance mammalian axon regeneration, only a few studies have shown convincing results, especially in the central nervous system. Wang et al. demonstrate that the deletion of non-muscle myosin II sufficiently induces significant mammalian CNS axon regeneration in vivo.

AB - Although modulating the neuronal cytoskeleton has been deemed a promising approach to enhance mammalian axon regeneration, only a few studies have shown convincing results, especially in the central nervous system. Wang et al. demonstrate that the deletion of non-muscle myosin II sufficiently induces significant mammalian CNS axon regeneration in vivo.

KW - Lin28

KW - axon regeneration

KW - cytoskeleton

KW - growth cone

KW - non-muscle myosin II

KW - optic nerve regeneration

KW - post-injury treatment

KW - retinal ganglion cells

KW - retraction bulb

UR - http://www.scopus.com/inward/record.url?scp=85083326747&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85083326747&partnerID=8YFLogxK

U2 - 10.1016/j.celrep.2020.107537

DO - 10.1016/j.celrep.2020.107537

M3 - Article

C2 - 32320663

AN - SCOPUS:85083326747

SN - 2211-1247

VL - 31

JO - Cell Reports

JF - Cell Reports

IS - 3

M1 - 107537

ER -

Knocking Out Non-muscle Myosin II in Retinal Ganglion Cells Promotes Long-Distance Optic Nerve Regeneration

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this