KLF4 modulates expression of IL-6 in dendritic cells via both promoter activation and epigenetic modification

Jason M. Rosenzweig; Justin D. Glenn; Peter A. Calabresi; Katharine A. Whartenby

doi:10.1074/jbc.M113.479576

KLF4 modulates expression of IL-6 in dendritic cells via both promoter activation and epigenetic modification

Jason M. Rosenzweig, Justin D. Glenn, Peter A. Calabresi, Katharine A. Whartenby

School of Medicine

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Background: Kruppel-like factor 4 (KLF4) is a zinc finger transcription factor that influences immunity. Results: KLF4 binds to CACCC sequences in the IL-6 promoter, directly activates transcription, and impacts promoter acetylation. Conclusion: KLF4 modulates IL-6 production by dendritic cells via both a direct transcriptional activation and epigenetic modification of the promoter. Significance: KLF4 plays a significant and previously unrecognized role in regulation of IL-6.

Original language	English (US)
Pages (from-to)	23868-23874
Number of pages	7
Journal	Journal of Biological Chemistry
Volume	288
Issue number	33
DOIs	https://doi.org/10.1074/jbc.M113.479576
State	Published - Aug 16 2013

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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title = "KLF4 modulates expression of IL-6 in dendritic cells via both promoter activation and epigenetic modification",

abstract = "Background: Kruppel-like factor 4 (KLF4) is a zinc finger transcription factor that influences immunity. Results: KLF4 binds to CACCC sequences in the IL-6 promoter, directly activates transcription, and impacts promoter acetylation. Conclusion: KLF4 modulates IL-6 production by dendritic cells via both a direct transcriptional activation and epigenetic modification of the promoter. Significance: KLF4 plays a significant and previously unrecognized role in regulation of IL-6.",

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AU - Rosenzweig, Jason M.

AU - Glenn, Justin D.

AU - Calabresi, Peter A.

AU - Whartenby, Katharine A.

PY - 2013/8/16

Y1 - 2013/8/16

N2 - Background: Kruppel-like factor 4 (KLF4) is a zinc finger transcription factor that influences immunity. Results: KLF4 binds to CACCC sequences in the IL-6 promoter, directly activates transcription, and impacts promoter acetylation. Conclusion: KLF4 modulates IL-6 production by dendritic cells via both a direct transcriptional activation and epigenetic modification of the promoter. Significance: KLF4 plays a significant and previously unrecognized role in regulation of IL-6.

AB - Background: Kruppel-like factor 4 (KLF4) is a zinc finger transcription factor that influences immunity. Results: KLF4 binds to CACCC sequences in the IL-6 promoter, directly activates transcription, and impacts promoter acetylation. Conclusion: KLF4 modulates IL-6 production by dendritic cells via both a direct transcriptional activation and epigenetic modification of the promoter. Significance: KLF4 plays a significant and previously unrecognized role in regulation of IL-6.

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KLF4 modulates expression of IL-6 in dendritic cells via both promoter activation and epigenetic modification

Abstract

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