KLF4 modulates expression of IL-6 in dendritic cells via both promoter activation and epigenetic modification

Jason M. Rosenzweig, Justin D. Glenn, Peter A. Calabresi, Katharine A. Whartenby

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Kruppel-like factor 4 (KLF4) is a zinc finger transcription factor that influences immunity. Results: KLF4 binds to CACCC sequences in the IL-6 promoter, directly activates transcription, and impacts promoter acetylation. Conclusion: KLF4 modulates IL-6 production by dendritic cells via both a direct transcriptional activation and epigenetic modification of the promoter. Significance: KLF4 plays a significant and previously unrecognized role in regulation of IL-6.

Original languageEnglish (US)
Pages (from-to)23868-23874
Number of pages7
JournalJournal of Biological Chemistry
Volume288
Issue number33
DOIs
StatePublished - Aug 16 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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