TY - JOUR
T1 - KIR2DL2 enhances protective and detrimental HLA class I-mediated immunity in chronic viral infection
AU - Seich al Basatena, Nafisa Katrin
AU - MacNamara, Aidan
AU - Vine, Alison M.
AU - Thio, Chloe L.
AU - Astemborski, Jacquie
AU - Usuku, Koichiro
AU - Osame, Mitsuhiro
AU - Kirk, Gregory D.
AU - Donfield, Sharyne M.
AU - Goedert, James J.
AU - Bangham, Charles R.M.
AU - Carrington, Mary
AU - Khakoo, Salim I.
AU - Asquith, Becca
PY - 2011/10
Y1 - 2011/10
N2 - Killer cell immunoglobulin-like receptors (KIRs) influence both innate and adaptive immunity. But while the role of KIRs in NK-mediated innate immunity is well-documented, the impact of KIRs on the T cell response in human disease is not known. Here we test the hypothesis that an individual's KIR genotype affects the efficiency of their HLA class I-mediated antiviral immune response and the outcome of viral infection. We show that, in two unrelated viral infections, hepatitis C virus and human T lymphotropic virus type 1, possession of the KIR2DL2 gene enhanced both protective and detrimental HLA class I-restricted anti-viral immunity. These results reveal a novel role for inhibitory KIRs. We conclude that inhibitory KIRs, in synergy with T cells, are a major determinant of the outcome of persistent viral infection.
AB - Killer cell immunoglobulin-like receptors (KIRs) influence both innate and adaptive immunity. But while the role of KIRs in NK-mediated innate immunity is well-documented, the impact of KIRs on the T cell response in human disease is not known. Here we test the hypothesis that an individual's KIR genotype affects the efficiency of their HLA class I-mediated antiviral immune response and the outcome of viral infection. We show that, in two unrelated viral infections, hepatitis C virus and human T lymphotropic virus type 1, possession of the KIR2DL2 gene enhanced both protective and detrimental HLA class I-restricted anti-viral immunity. These results reveal a novel role for inhibitory KIRs. We conclude that inhibitory KIRs, in synergy with T cells, are a major determinant of the outcome of persistent viral infection.
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U2 - 10.1371/journal.ppat.1002270
DO - 10.1371/journal.ppat.1002270
M3 - Article
C2 - 22022261
AN - SCOPUS:80055091825
SN - 1553-7366
VL - 7
JO - PLoS pathogens
JF - PLoS pathogens
IS - 10
M1 - e1002270
ER -