Kinetics study of immunological response to Clostridium botulinum toxin

M. Dezfulian, R. A. Bitar, J. G. Bartlett

Research output: Contribution to journalArticlepeer-review

Abstract

A double-antibody enzyme-linked immunosorbent assay (ELISA) for detection of humoral antibody to type A botulinal toxin was developed. This assay was used to study the kinetics of antibody response of a volunteer to botulinal toxoid. The circulating type A antitoxin was first detected by the ELISA 2 weeks after the first booster injection of the toxoid. The antibody titer stayed level until the second booster at 12 weeks. The titer then continued to rise throughout the remaining study period. The neutralizing antibody to type A toxin was detected by mouse assay 15 weeks after detection of antitoxin by the ELISA.

Original languageEnglish (US)
Pages (from-to)1336-1337
Number of pages2
JournalJournal of clinical microbiology
Volume25
Issue number7
DOIs
StatePublished - 1987

ASJC Scopus subject areas

  • Microbiology (medical)

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