TY - JOUR
T1 - Kinetics of IgM and IgG responses to japanese encephalitis virus in human serum and cerebrospinal fluid
AU - Burke, Donald S.
AU - Nisalak, Ananda
AU - Ussery, Michael A.
AU - Laorakpongse, Thanom
AU - Chantavibul, Suchard
PY - 1985/6/1
Y1 - 1985/6/1
N2 - We measured levels of antibodies to Japanese encephalitis virus (JEV) in serum and in cerebrospinal fluid (CSF) specimens obtained from 32 patients with acute encephalitis by using “antibody-capture” solid-phase enzyme-linked immunoassays specific for IgM or IgO to JEV. The proportions of confirmed cases with IgM to lEV detectable in CSF were 68% (obtained on day 1), 100% (day 7), 96% (day 30), and 72% (day 180). For IgO in CSF the proportions were 47% (day 1), 89% (day 7), 100% (day 30), and 100% (day 180). Twenty-five CSF samples were obtained from control patients with other diseases with possible nervous system involvement (but none with a clinical diagnosis of viral encephalitis); none had detectable IgM to JEV. Five JEV-infected but asymptomatic siblings of patients with encephalitis were also examined; all had high levels of IgM to JEV in serum, but none had detectable IgM to JEV in CSF.
AB - We measured levels of antibodies to Japanese encephalitis virus (JEV) in serum and in cerebrospinal fluid (CSF) specimens obtained from 32 patients with acute encephalitis by using “antibody-capture” solid-phase enzyme-linked immunoassays specific for IgM or IgO to JEV. The proportions of confirmed cases with IgM to lEV detectable in CSF were 68% (obtained on day 1), 100% (day 7), 96% (day 30), and 72% (day 180). For IgO in CSF the proportions were 47% (day 1), 89% (day 7), 100% (day 30), and 100% (day 180). Twenty-five CSF samples were obtained from control patients with other diseases with possible nervous system involvement (but none with a clinical diagnosis of viral encephalitis); none had detectable IgM to JEV. Five JEV-infected but asymptomatic siblings of patients with encephalitis were also examined; all had high levels of IgM to JEV in serum, but none had detectable IgM to JEV in CSF.
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U2 - 10.1093/infdis/151.6.1093
DO - 10.1093/infdis/151.6.1093
M3 - Article
C2 - 2987367
AN - SCOPUS:0021811585
SN - 0022-1899
VL - 151
SP - 1093
EP - 1099
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 6
ER -