Kinetics of cellular and humoral response of rabbits immunized with Mycoplasma pneumoniae

K. K. Tu, K. Wicher, N. R. Rose

Research output: Contribution to journalArticle

Abstract

The cellular and humoral responses of rabbits immunized with Mycoplasma pneumoniae antigen in saline or incorporated in Freund's complete adjuvant were examined. Peripheral blood leucocytes were used for the leukocyte migration inhibition (LMI) test. Both groups of animals showed significant LMI activity in the presence of M. pneumoniae as well as crossreacting M. salivarium antigens but response to M. pneumoniae antigen was more pronounced. In the humoral response no such cross-reactivity was observed. Although some of the animals (3/8) demonstrated antibodies to M. salivarium prior to immunization the titers were not influenced by the immunization with M. pneumoniae antigen. Both groups of animals produced antibodies to M. pneumoniae antigen only, but significantly higher titers were observed in the adjuvant group. Cold hemagglutinins in both groups appeared earlier than the specific antibodies to mycoplasma. The adjuvant had no effect on the production of the cold agglutinins.

Original languageEnglish (US)
Pages (from-to)263-277
Number of pages15
JournalImmunological Communications
Volume8
Issue number3
StatePublished - 1979
Externally publishedYes

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Mycoplasma pneumoniae
Rabbits
Antigens
Antibodies
Immunization
Leukocytes
Leukocyte Cell Migration Assays
Freund's Adjuvant
Mycoplasma
Hemagglutinins

ASJC Scopus subject areas

  • Immunology

Cite this

Kinetics of cellular and humoral response of rabbits immunized with Mycoplasma pneumoniae. / Tu, K. K.; Wicher, K.; Rose, N. R.

In: Immunological Communications, Vol. 8, No. 3, 1979, p. 263-277.

Research output: Contribution to journalArticle

Tu, K. K. ; Wicher, K. ; Rose, N. R. / Kinetics of cellular and humoral response of rabbits immunized with Mycoplasma pneumoniae. In: Immunological Communications. 1979 ; Vol. 8, No. 3. pp. 263-277.
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