Kinetics of a putative hypoxic tissue marker, technetium-99m- nitroimidazole (BMS181321), in normoxic, hypoxic, ischemic and stunned myocardium

H. Kusuoka, K. Hashimoto, K. Fukuchi, T. Nishimura

Research output: Contribution to journalArticlepeer-review

Abstract

This study focused on the kinetics of the newly developed 99mTc- nitroimidazole, propyleneamine oxime-1,2-nitroimidazole (BMS181321) in the different setting of myocardial perfusion states and oxygenation levels, and compared the kinetics of BMS181321 with those of other technetium analogues. Methods: The kinetics of BMS181321 were evaluated in isolated perfused rat hearts. Technetium-99m-hexamethyl propyleneamine oxime (HMPAO) and a non- nitroimidazole-containing analogue of BMS181321 (6-methyl propyleneamine oxime; PAO-6-Me) were used to compare their kinetics with those of BMS181321. Results: BMS181321 cleared quickly from normoxic hearts and the retention in the myocardium 10 min after injection was 0.84% ± 0.04% ID/g wet wt (mean ± s.e.m.). In contrast, BMS181321 was retained after reperfusion when it was injected before ischemia; the uptake in the myocardium 10 min after reperfusion was significantly greater than in controls (23.9% ± 3.9% ID/g wt, p < 0.05). Conclusions: These results indicate that 99mTc-BMS181321 is well trapped in ischemic myocardium and moderately trapped in hypoxic myocardium, but washed out quickly in stunned myocardium. The residence time influences the amount retained.

Original languageEnglish (US)
Pages (from-to)1371-1376
Number of pages6
JournalJournal of Nuclear Medicine
Volume35
Issue number8
StatePublished - 1994

Keywords

  • hypoxia
  • myocardium
  • nitroimidazole
  • stunning
  • technetium-99m

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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