Kinetic Vitreous Fluorophotometry in Normals and Noninsulin-Dependent Diabetics

Kinetic vitreous fluorophotometry was performed up to five hours after intravenous injection of fluorescein in seven normal subjects and seven noninsulin-dependent diabetic patients without retinopathy. The leakage of fluorescein into the vitreous was measured, and fluorescein dynamics were assessed after correction for the most important artifacts. A detailed description of the movements of fluorescein between the blood and the chambers of the eye across the blood-ocular barriers was obtained in normal and diabetic eyes. The diabetic population could be differentiated best from the normal one with vitreous fluorophotometry measurements performed close to the retina-choroid one hour after injection.