Kinase activity of mutant LRRK2 mediates neuronal toxicity

Research output: Contribution to journalArticlepeer-review

Abstract

Mutations in the the leucine-rich repeat kinase-2 (LRRK2) gene cause autosomal-dominant Parkinson disease and some cases of sporadic Parkinson disease. Here we found that LRRK2 kinase activity was regulated by GTP via the intrinsic GTPase Roc domain, and alterations of LRRK2 protein that reduced kinase activity of mutant LRRK2 correspondingly reduced neuronal toxicity. These data elucidate the pathogenesis of LRRK2-linked Parkinson disease, potentially illuminate mechanisms of sporadic Parkinson disease and suggest therapeutic targets.

Original languageEnglish (US)
Pages (from-to)1231-1233
Number of pages3
JournalNature neuroscience
Volume9
Issue number10
DOIs
StatePublished - Oct 2006

ASJC Scopus subject areas

  • Neuroscience(all)

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