Killer artificial antigen-presenting cells: The synthetic embodiment of a 'guided missile'

Christian Schütz, Mathias Oelke, Jonathan P. Schneck, Andreas MacKensen, Martin Fleck

Research output: Contribution to journalReview article

Abstract

At present, the treatment of T-cell-dependent autoimmune diseases relies exclusively on strategies leading to nonspecific suppression of the immune systems causing a substantial reduced ability to control concomitant infections or malignancies. Furthermore, long-term treatment with most drugs is accompanied by several serious adverse effects and does not consequently result in cure of the primary immunological malfunction. By contrast, antigen-specific immunotherapy offers the potential to achieve the highest therapeutic efficiency in accordance with minimal adverse effects. Therefore, several studies have been performed utilizing antigen-presenting cells specifically engineered to deplete allo- or antigen-specific T cells ('guided missiles). Many of these strategies take advantage of the Fas/Fas ligand signaling pathway to efficiently induce antigen-presenting cell-mediated apoptosis in targeted T cells. In this article, we discuss the advantages and shortcomings of a novel non-cell-based 'killer artificial antigen-presenting cell strategy, developed to overcome obstacles related to current cell-based approaches for the treatment of T-cell-mediated autoimmunity.

Original languageEnglish (US)
Pages (from-to)539-550
Number of pages12
JournalImmunotherapy
Volume2
Issue number4
DOIs
StatePublished - Jul 1 2010

Keywords

  • T cell
  • antigen-presenting cell
  • apoptosis
  • artificial
  • killer artificial antigen-presenting cell

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology

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