Kidney paired donation and optimizing the use of live donor organs

Dorry L. Segev, Sommer E. Gentry, Daniel S. Warren, Brigitte Reeb, Robert A. Montgomery

Research output: Contribution to journalArticle

Abstract

Context: Blood type and crossmatch incompatibility will exclude at least one third of patients in need from receiving a live donor kidney transplant. Kidney paired donation (KPD) offers incompatible donor/recipient pairs the opportunity to match for compatible transplants. Despite its increasing popularity, very few transplants have resulted from KPD. Objective: To determine the potential impact of improved matching schemes on the number and quality of transplants achievable with KPD. Design, Setting, and Population: We developed a model that simulates pools of incompatible donor/recipient pairs. We designed a mathematically verifiable optimized matching algorithm and compared it with the scheme currently used in some centers and regions. Simulated patients from the general community with characteristics drawn from distributions describing end-stage renal disease patients eligible for renal transplantation and their willing and eligible live donors. Main Outcome Measures: Number of kidneys matched, HLA mismatch of matched kidneys, and number of grafts surviving 5 years after transplantation. Results: A national optimized matching algorithm would result in more transplants (47.7% vs 42.0%, P

Original languageEnglish (US)
Pages (from-to)1883-1890
Number of pages8
JournalJournal of the American Medical Association
Volume293
Issue number15
DOIs
StatePublished - Apr 20 2005

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Tissue Donors
Transplants
Kidney
Kidney Transplantation
Chronic Kidney Failure
Transplantation
Outcome Assessment (Health Care)
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kidney paired donation and optimizing the use of live donor organs. / Segev, Dorry L.; Gentry, Sommer E.; Warren, Daniel S.; Reeb, Brigitte; Montgomery, Robert A.

In: Journal of the American Medical Association, Vol. 293, No. 15, 20.04.2005, p. 1883-1890.

Research output: Contribution to journalArticle

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