Kidney function as a predictor of loss of lean mass in older adults

Health, aging and body composition study

Linda F. Fried, Robert Boudreau, Jung Sun Lee, Glenn Chertow, Manjula Kurella-Tamura, Michael G. Shlipak, Jingzhong Ding, Deborah Sellmeyer, Frances A. Tylavsky, Eleanor Simsonick, Stephen B. Kritchevsky, Tamara B. Harris, Anne B. Newman

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: To assess the association between kidney function and change in body composition in older individuals. DESIGN: Prospective cohort study. SETTING: Two sites, Pittsburgh, Pennsylvania, and Memphis, Tennessee. PARTICIPANTS: Three thousand twenty-six well-functioning, participants aged 70 to 79 in the Health, Aging and Body Composition Study. MEASUREMENTS: Body composition (bone-free lean mass and fat mass) was measured using dual x-ray absorptiometry annually for 4 years. Kidney function was measured at baseline according to serum creatinine (SCr). Comorbidity and inflammatory markers were evaluated as covariates in mixed-model, repeated-measures analysis. RESULTS: High SCr was associated with loss of lean mass in men but not women, with a stronger relationship in black men (P=.02 for difference between slopes for white and black men). In white men, after adjustment for age and comorbidity, higher SCr remained associated with loss of lean mass (-0.07±0.03 kg/y greater loss per 0.4 mg/dL (1 standard deviation (SD)), P=.009) but was attenuated after adjustment for inflammatory factors (-0.05±0.03 kg/y greater loss per SD, P=.10). In black men, the relationship between SCr and loss of lean mass (-0.19±0.04 kg/y per SD, P

Original languageEnglish (US)
Pages (from-to)1578-1584
Number of pages7
JournalJournal of the American Geriatrics Society
Volume55
Issue number10
DOIs
StatePublished - Oct 2007
Externally publishedYes

Fingerprint

Body Composition
Creatinine
Kidney
Health
Serum
Comorbidity
Cohort Studies
Fats
X-Rays
Prospective Studies
Bone and Bones

Keywords

  • Body composition
  • Elderly
  • Kidney function
  • Sarcopenia
  • Weight loss

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Fried, L. F., Boudreau, R., Lee, J. S., Chertow, G., Kurella-Tamura, M., Shlipak, M. G., ... Newman, A. B. (2007). Kidney function as a predictor of loss of lean mass in older adults: Health, aging and body composition study. Journal of the American Geriatrics Society, 55(10), 1578-1584. https://doi.org/10.1111/j.1532-5415.2007.01398.x

Kidney function as a predictor of loss of lean mass in older adults : Health, aging and body composition study. / Fried, Linda F.; Boudreau, Robert; Lee, Jung Sun; Chertow, Glenn; Kurella-Tamura, Manjula; Shlipak, Michael G.; Ding, Jingzhong; Sellmeyer, Deborah; Tylavsky, Frances A.; Simsonick, Eleanor; Kritchevsky, Stephen B.; Harris, Tamara B.; Newman, Anne B.

In: Journal of the American Geriatrics Society, Vol. 55, No. 10, 10.2007, p. 1578-1584.

Research output: Contribution to journalArticle

Fried, LF, Boudreau, R, Lee, JS, Chertow, G, Kurella-Tamura, M, Shlipak, MG, Ding, J, Sellmeyer, D, Tylavsky, FA, Simsonick, E, Kritchevsky, SB, Harris, TB & Newman, AB 2007, 'Kidney function as a predictor of loss of lean mass in older adults: Health, aging and body composition study', Journal of the American Geriatrics Society, vol. 55, no. 10, pp. 1578-1584. https://doi.org/10.1111/j.1532-5415.2007.01398.x
Fried, Linda F. ; Boudreau, Robert ; Lee, Jung Sun ; Chertow, Glenn ; Kurella-Tamura, Manjula ; Shlipak, Michael G. ; Ding, Jingzhong ; Sellmeyer, Deborah ; Tylavsky, Frances A. ; Simsonick, Eleanor ; Kritchevsky, Stephen B. ; Harris, Tamara B. ; Newman, Anne B. / Kidney function as a predictor of loss of lean mass in older adults : Health, aging and body composition study. In: Journal of the American Geriatrics Society. 2007 ; Vol. 55, No. 10. pp. 1578-1584.
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