Kidney function and blood pressure: A Bi-directional mendelian randomisation study

Zhi Yu, Josef Coresh, Guanghao Qi, Morgan Grams, Eric Boerwinkle, Harold Snieder, Alexander Teumer, Cristian Pattaro, Anna Köttgen, Nilanjan Chatterjee, Adrienne Tin

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To evaluate the bi-directional causal relation between kidney function and blood pressure. Design: Mendelian randomisation study. Setting: We performed two-sample Mendelian randomisation analyses. Genetic instruments of kidney function traits were selected from summary statistics of genome-wide association studies (GWAS) of glomerular filtration rate estimated from serum creatinine (eGFRcr) and blood urea nitrogen (BUN) and were required to be associated with both eGFRcr and BUN to ensure that the instruments were more likely to represent the underlying kidney function. Genetic instruments of blood pressure were selected from summary statistics of GWAS of systolic and diastolic blood pressure. We investigated Mendelian randomisation hypothesis using several alternative approaches, including methods that are most robust to the presence of horizontal pleiotropy. Participants: The summary statistics of eGFRcr included 567,460 participants from 54 cohorts, and the summary statistics of BUN included 243,031 participants from 48 cohorts from the Chronic Kidney Disease Genetics (CKDGen) Consortium. The summary statistics of systolic and diastolic blood pressure included 757,601 participants from the UK Biobank and 78 cohorts from the International Consortium for Blood Pressure (ICBP).

Original languageEnglish (US)
JournalUnknown Journal
DOIs
StatePublished - Nov 29 2019

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • Immunology and Microbiology(all)
  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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