Kidney disease in diabetes

Stephanie Toth-Manikowski; Mohamed G. Atta

doi:10.1016/B978-0-12-801238-3.95806-9

Kidney disease in diabetes

Stephanie Toth-Manikowski, Mohamed G. Atta

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Renal involvement of DM is collectively known as diabetic kidney disease (DKD). DKD is initially characterized by hyperfiltration in many patients which is eventually followed by a reduction in glomerular filtration rate and ultimately, progression to end stage kidney disease. Renal pathogenesis occurs as a result of aberrancies in various pathways including the hemodynamic, metabolic, inflammatory, genetic, and alternative pathways which are discussed in further detail in the chapter. While newer treatment modalities attempt to address various aberrations in these pathways, the mainstay of DKD management still focuses on renin-angiotensin-aldosterone system inhibition, glycemic and blood pressure control.

Original language	English (US)
Title of host publication	Encyclopedia of Endocrine Diseases
Publisher	Elsevier
Pages	202-206
Number of pages	5
ISBN (Electronic)	9780128122006
ISBN (Print)	9780128121993
DOIs	https://doi.org/10.1016/B978-0-12-801238-3.95806-9
State	Published - Jan 1 2018

Keywords

Diabetic kidney disease
Diabetic nephropathy
End stage kidney disease
Pathophysiology

ASJC Scopus subject areas

General Medicine

Access to Document

10.1016/B978-0-12-801238-3.95806-9

Cite this

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AB - Renal involvement of DM is collectively known as diabetic kidney disease (DKD). DKD is initially characterized by hyperfiltration in many patients which is eventually followed by a reduction in glomerular filtration rate and ultimately, progression to end stage kidney disease. Renal pathogenesis occurs as a result of aberrancies in various pathways including the hemodynamic, metabolic, inflammatory, genetic, and alternative pathways which are discussed in further detail in the chapter. While newer treatment modalities attempt to address various aberrations in these pathways, the mainstay of DKD management still focuses on renin-angiotensin-aldosterone system inhibition, glycemic and blood pressure control.

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KW - Pathophysiology

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ER -

Kidney disease in diabetes

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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