Abstract
Certain metals are harmful to the kidney and liver at high levels, but associations with functional biomarkers at low exposure levels among premenopausal women apparently has not been evaluated. Healthy, regularly menstruating women (n = 259) were followed for up to 2 menstrual cycles with up to 16 visits. Renal and liver biomarkers were measured in serum at each clinic visit. Cadmium (Cd), lead (Pb), and mercury (Hg) were measured in whole blood at baseline. Linear mixed models were adjusted for age, body mass index (BMI), race, average calories, alcohol intake, smoking, and cycle day. Median levels of Cd, Pb, and Hg were 0.31 g/L, 0.88 μg/dl, and 1.1 μg/L, respectively. One-third of women had diminished glomerular filtration rate (eGFR) (2). Each twofold increase in Cd was associated with a negative 4.9% change in blood urea nitrogen (BUN) and bilirubin. Each twofold rise in Pb was associated with decreased eGFR and increased creatinine. A twofold elevation in Hg was associated with higher protein and reduced alkaline phosphatase. In healthy, predominantly nonsmoking women, low levels of Cd, Pb, and Hg were associated with changes in select biomarkers of kidney and liver function.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 119-131 |
| Number of pages | 13 |
| Journal | Journal of Toxicology and Environmental Health - Part A: Current Issues |
| Volume | 78 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 17 2015 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Health, Toxicology and Mutagenesis
- Toxicology
- Medicine(all)
Cite this
Kidney biomarkers associated with blood lead, mercury, and cadmium in premenopausal women : A prospective cohort study. / Pollack, Anna Z.; Mumford, Sunni L.; Mendola, Pauline; Perkins, Neil J.; Rotman, Yaron; Wactawski-Wende, Jean; Schisterman, Enrique F.
In: Journal of Toxicology and Environmental Health - Part A: Current Issues, Vol. 78, No. 2, 17.01.2015, p. 119-131.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Kidney biomarkers associated with blood lead, mercury, and cadmium in premenopausal women
T2 - A prospective cohort study
AU - Pollack, Anna Z.
AU - Mumford, Sunni L.
AU - Mendola, Pauline
AU - Perkins, Neil J.
AU - Rotman, Yaron
AU - Wactawski-Wende, Jean
AU - Schisterman, Enrique F.
PY - 2015/1/17
Y1 - 2015/1/17
N2 - Certain metals are harmful to the kidney and liver at high levels, but associations with functional biomarkers at low exposure levels among premenopausal women apparently has not been evaluated. Healthy, regularly menstruating women (n = 259) were followed for up to 2 menstrual cycles with up to 16 visits. Renal and liver biomarkers were measured in serum at each clinic visit. Cadmium (Cd), lead (Pb), and mercury (Hg) were measured in whole blood at baseline. Linear mixed models were adjusted for age, body mass index (BMI), race, average calories, alcohol intake, smoking, and cycle day. Median levels of Cd, Pb, and Hg were 0.31 g/L, 0.88 μg/dl, and 1.1 μg/L, respectively. One-third of women had diminished glomerular filtration rate (eGFR) (2). Each twofold increase in Cd was associated with a negative 4.9% change in blood urea nitrogen (BUN) and bilirubin. Each twofold rise in Pb was associated with decreased eGFR and increased creatinine. A twofold elevation in Hg was associated with higher protein and reduced alkaline phosphatase. In healthy, predominantly nonsmoking women, low levels of Cd, Pb, and Hg were associated with changes in select biomarkers of kidney and liver function.
AB - Certain metals are harmful to the kidney and liver at high levels, but associations with functional biomarkers at low exposure levels among premenopausal women apparently has not been evaluated. Healthy, regularly menstruating women (n = 259) were followed for up to 2 menstrual cycles with up to 16 visits. Renal and liver biomarkers were measured in serum at each clinic visit. Cadmium (Cd), lead (Pb), and mercury (Hg) were measured in whole blood at baseline. Linear mixed models were adjusted for age, body mass index (BMI), race, average calories, alcohol intake, smoking, and cycle day. Median levels of Cd, Pb, and Hg were 0.31 g/L, 0.88 μg/dl, and 1.1 μg/L, respectively. One-third of women had diminished glomerular filtration rate (eGFR) (2). Each twofold increase in Cd was associated with a negative 4.9% change in blood urea nitrogen (BUN) and bilirubin. Each twofold rise in Pb was associated with decreased eGFR and increased creatinine. A twofold elevation in Hg was associated with higher protein and reduced alkaline phosphatase. In healthy, predominantly nonsmoking women, low levels of Cd, Pb, and Hg were associated with changes in select biomarkers of kidney and liver function.
UR - http://www.scopus.com/inward/record.url?scp=84913528893&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84913528893&partnerID=8YFLogxK
U2 - 10.1080/15287394.2014.944680
DO - 10.1080/15287394.2014.944680
M3 - Article
C2 - 25424620
AN - SCOPUS:84913528893
VL - 78
SP - 119
EP - 131
JO - Journal of Toxicology and Environmental Health - Part A: Current Issues
JF - Journal of Toxicology and Environmental Health - Part A: Current Issues
SN - 1528-7394
IS - 2
ER -