Kidney allograft survival of African American and Caucasian American recipients with lupus

G. Contreras, H. Li, M. Gonzalez-Suarez, T. Isakova, J. J. Scialla, F. Pedraza, A. Mattiazzi, R. Diaz-Wong, J. Sageshima, Y. Brito, G. Guerra, B. Acevedo, A. Sajid Ali, T. J. Kershaw, L. Chen, G. W. Burke, W. Kupin, G. Ciancio, D. Roth

Research output: Contribution to journalArticle

Abstract

Background: African Americans with lupus who receive kidney transplants have high prevalence of predictors of allograft failure, which can explain their poor outcomes. Methods: Of 1223 African Americans and 1029 Caucasian Americans with lupus who received kidney transplants from deceased donors between 1987 and 2006 with complete records in the UNOS program, 741 pairs were matched in 16 predictors employing a predicted probability of group membership. The primary outcome was allograft failure. Main secondary outcomes were rejection, allograft failure due to rejection, and mortality. Results: Matched pairs were predominantly women (82%) with a mean age of 39 years. Twenty-four percent of recipients received kidneys from expanded criteria donors. African Americans and Caucasian Americans matched well (p≥0.05): donor age, gender and race; recipient age, gender, education and insurance; dialysis prior to transplant, kidneys from expanded criteria donors, cold ischemia time, history of prior kidney transplant, panel reactive antibodies, human leukocyte antigens mismatch, blood type compatibility, transplant Era, and follow-up time. Contrary to the unmatched cohort with significantly higher allograft failure rate (events per 100 patientyears) in African Americans compared to Caucasian Americans (10.49 vs 6.18, p

Original languageEnglish (US)
Pages (from-to)151-158
Number of pages8
JournalLupus
Volume23
Issue number2
DOIs
StatePublished - Feb 2014
Externally publishedYes

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African Americans
Allografts
Transplants
Kidney
Tissue Donors
Cold Ischemia
HLA Antigens
Insurance
Dialysis
Education
Mortality
Antibodies

Keywords

  • Nephritis
  • renal lupus
  • systemic lupus erythematosus

ASJC Scopus subject areas

  • Rheumatology

Cite this

Contreras, G., Li, H., Gonzalez-Suarez, M., Isakova, T., Scialla, J. J., Pedraza, F., ... Roth, D. (2014). Kidney allograft survival of African American and Caucasian American recipients with lupus. Lupus, 23(2), 151-158. https://doi.org/10.1177/0961203313513819

Kidney allograft survival of African American and Caucasian American recipients with lupus. / Contreras, G.; Li, H.; Gonzalez-Suarez, M.; Isakova, T.; Scialla, J. J.; Pedraza, F.; Mattiazzi, A.; Diaz-Wong, R.; Sageshima, J.; Brito, Y.; Guerra, G.; Acevedo, B.; Ali, A. Sajid; Kershaw, T. J.; Chen, L.; Burke, G. W.; Kupin, W.; Ciancio, G.; Roth, D.

In: Lupus, Vol. 23, No. 2, 02.2014, p. 151-158.

Research output: Contribution to journalArticle

Contreras, G, Li, H, Gonzalez-Suarez, M, Isakova, T, Scialla, JJ, Pedraza, F, Mattiazzi, A, Diaz-Wong, R, Sageshima, J, Brito, Y, Guerra, G, Acevedo, B, Ali, AS, Kershaw, TJ, Chen, L, Burke, GW, Kupin, W, Ciancio, G & Roth, D 2014, 'Kidney allograft survival of African American and Caucasian American recipients with lupus', Lupus, vol. 23, no. 2, pp. 151-158. https://doi.org/10.1177/0961203313513819
Contreras G, Li H, Gonzalez-Suarez M, Isakova T, Scialla JJ, Pedraza F et al. Kidney allograft survival of African American and Caucasian American recipients with lupus. Lupus. 2014 Feb;23(2):151-158. https://doi.org/10.1177/0961203313513819
Contreras, G. ; Li, H. ; Gonzalez-Suarez, M. ; Isakova, T. ; Scialla, J. J. ; Pedraza, F. ; Mattiazzi, A. ; Diaz-Wong, R. ; Sageshima, J. ; Brito, Y. ; Guerra, G. ; Acevedo, B. ; Ali, A. Sajid ; Kershaw, T. J. ; Chen, L. ; Burke, G. W. ; Kupin, W. ; Ciancio, G. ; Roth, D. / Kidney allograft survival of African American and Caucasian American recipients with lupus. In: Lupus. 2014 ; Vol. 23, No. 2. pp. 151-158.
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