Key Pharmacokinetic Essentials of Fixed-Dosed Combination Products: Case Studies and Perspectives

Ranjeet Prasad Dash, Rana Rais, Nuggehally R. Srinivas

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Fixed-dose combinations are gaining popularity because they provide convenience while enhancing patient compliance. Literature examples suggest that many fixed-dose combinations are being rationalized and investigated for their potential utility in therapy. This article provides an introspection into the pharmacokinetic essentials that need to be considered prior to implementing a fixed-dose combination strategy. While the drug–drug interaction potential is an important question for the two drugs in a fixed-dose combination, the occurrence of a drug–drug interaction in itself is not a negative outcome for the proposed fixed-dose combination. However, the magnitude of a drug–drug interaction may require a re-assessment of the doses of the two drugs in a fixed-dose combination. Several case studies are provided and discussed to provide a broad perspective on the topic along with a representative framework and strategy on the development of fixed-dose combinations using key pharmacokinetic parameters.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalClinical Pharmacokinetics
StateAccepted/In press - Aug 8 2017

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


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