Key concepts and limitations of statistical methods for evaluating biomarkers of kidney disease

Research output: Contribution to journalReview article

Abstract

Interest indevelopingandusingnovelmarkers of kidney injury is increasing. Tomaintain scientific rigour in these endeavors, a comprehensive understanding of statistical methodology is required to rigorously assess the incremental value of novel biomarkers in existing clinical risk prediction models. Such knowledge is especially relevant, because no single statistical method is sufficient to evaluate a novel biomarker. In this review, we highlight the strengths and limitations of various traditional and novel statistical methods used in the literature for biomarker studies and use biomarkers of AKI as examples to show limitations of some popular statistical methods.

Original languageEnglish (US)
Pages (from-to)1621-1629
Number of pages9
JournalJournal of the American Society of Nephrology
Volume25
Issue number8
DOIs
Publication statusPublished - Jan 1 2014

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ASJC Scopus subject areas

  • Nephrology

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