Ketogenic dietary therapies for epilepsy and beyond

Danielle M. DeCampo, Eric H. Kossoff

Research output: Contribution to journalReview articlepeer-review

Abstract

Purpose of reviewThe ketogenic diet, a high-fat, low-carbohydrate therapy, has become an established treatment for pediatric epilepsy since 1921. There has recently been an increase in important studies on the ketogenic diet, and this review will highlight the most recent in order to provide a synthesis of where this field stands today.Recent findingsClinical studies continue to support the use of ketogenic diets in epilepsy, with more recent trials supporting its use in adults. Clinical recommendations published in 2018 based on a decade of practice and research, guide implementation and management of the ketogenic diet in epilepsy. One of the most rapidly growing 'indications' includes the role of ketogenic diets in status epilepticus. An exciting new potential mechanism for how the ketogenic diet exerts its antiseizure effects is through changing the composition of the gut microbiome. Lastly, ketogenic diets are being applied to a range of neurological conditions from autism to Alzheimer's disease.SummaryThe ketogenic diet is a versatile therapy, with growing clinical evidence and guidelines, widely used for the treatment of epilepsy. New indications include status epilepticus and neurological conditions other than epilepsy.

Original languageEnglish (US)
Pages (from-to)264-268
Number of pages5
JournalCurrent opinion in clinical nutrition and metabolic care
Volume22
Issue number4
DOIs
StatePublished - Jul 1 2019

Keywords

  • epilepsy
  • gut microbiome
  • ketogenic diet
  • modified Atkins diet

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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