TY - JOUR
T1 - Ketogenic Diet Therapies for Seizures and Status Epilepticus
AU - McDonald, Tanya J.W.
AU - Cervenka, MacKenzie C.
N1 - Funding Information:
Dr. Cervenka reports grants and personal fees from Nutri-cia North America, grants from Vitaflo, personal fees from Demos Health, grants from William and Ella Owens Medical Research Foundation, grants from BrightFocus Foundation, and personal fees from Glut1 Deficiency Foundation, outside the submitted work. Dr. McDonald reports personal fees from Nutricia North America, outside the submitted work.
Publisher Copyright:
© 2020 Royal Society of Chemistry. All rights reserved.
PY - 2020/12/1
Y1 - 2020/12/1
N2 - Ketogenic diet therapies are high-fat, low-carbohydrate diets designed to mimic a fasting state. Although initially developed nearly one century ago for seizure management, most clinical trials for the management of drug-resistant epilepsy in children as well as adults have been conducted over the last 3 decades. Moreover, ketogenic diets offer promising new adjunctive strategies in the critical care setting for the resolution of acute status epilepticus when traditional antiseizure drugs and anesthetic agents fail. Here, we review the history of ketogenic diet development, the clinical evidence supporting its use for the treatment of drug-resistant epilepsy in children and adults, and the early evidence supporting ketogenic diet feasibility, safety, and potential efficacy in the management of status epilepticus.
AB - Ketogenic diet therapies are high-fat, low-carbohydrate diets designed to mimic a fasting state. Although initially developed nearly one century ago for seizure management, most clinical trials for the management of drug-resistant epilepsy in children as well as adults have been conducted over the last 3 decades. Moreover, ketogenic diets offer promising new adjunctive strategies in the critical care setting for the resolution of acute status epilepticus when traditional antiseizure drugs and anesthetic agents fail. Here, we review the history of ketogenic diet development, the clinical evidence supporting its use for the treatment of drug-resistant epilepsy in children and adults, and the early evidence supporting ketogenic diet feasibility, safety, and potential efficacy in the management of status epilepticus.
KW - epilepsy
KW - ketogenic diet
KW - modified Atkins diet
KW - refractory status epilepticus
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U2 - 10.1055/s-0040-1719077
DO - 10.1055/s-0040-1719077
M3 - Article
C2 - 33155184
AN - SCOPUS:85096075978
VL - 40
SP - 719
EP - 729
JO - Seminars in Neurology
JF - Seminars in Neurology
SN - 0271-8235
IS - 6
ER -