Ketogenic Diet Therapies for Seizures and Status Epilepticus

Tanya J.W. McDonald, MacKenzie C. Cervenka

Research output: Contribution to journalArticlepeer-review

Abstract

Ketogenic diet therapies are high-fat, low-carbohydrate diets designed to mimic a fasting state. Although initially developed nearly one century ago for seizure management, most clinical trials for the management of drug-resistant epilepsy in children as well as adults have been conducted over the last 3 decades. Moreover, ketogenic diets offer promising new adjunctive strategies in the critical care setting for the resolution of acute status epilepticus when traditional antiseizure drugs and anesthetic agents fail. Here, we review the history of ketogenic diet development, the clinical evidence supporting its use for the treatment of drug-resistant epilepsy in children and adults, and the early evidence supporting ketogenic diet feasibility, safety, and potential efficacy in the management of status epilepticus.

Original languageEnglish (US)
Pages (from-to)719-729
Number of pages11
JournalSeminars in neurology
Volume40
Issue number6
DOIs
StatePublished - Dec 1 2020

Keywords

  • epilepsy
  • ketogenic diet
  • modified Atkins diet
  • refractory status epilepticus

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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