Ketamine for refractory status epilepticus: A case of possible ketamine-induced neurotoxicity

Eroboghene E. Ubogu; Stephen M. Sagar; Alan J. Lerner; Brian N. Maddux; José I. Suarez; Mary Ann Werz

doi:10.1016/S1525-5050(02)00643-1

Ketamine for refractory status epilepticus: A case of possible ketamine-induced neurotoxicity

Eroboghene E. Ubogu, Stephen M. Sagar, Alan J. Lerner, Brian N. Maddux, José I. Suarez, Mary Ann Werz

Research output: Contribution to journal › Article › peer-review

87 Scopus citations

Abstract

A 44-year-old man with treated neurosyphilis presented with subclinical status epilepticus (SE) refractory to intravenous high-dose lorazepam, phenytoin, and valproic acid over 4 days. Ketamine infusion was instituted after low-dose propofol sedation with gradual control of electrographic seizures over 72 h. Reevaluation 3 months later revealed diffuse cerebellar and worsened cerebral atrophy, consistent with animal models of N-methyl-D-aspartate antagonist-mediated neurotoxicity. Animal studies of prolonged ketamine therapy are required before widespread human use in SE.

Original language	English (US)
Pages (from-to)	70-75
Number of pages	6
Journal	Epilepsy and Behavior
Volume	4
Issue number	1
DOIs	https://doi.org/10.1016/S1525-5050(02)00643-1
State	Published - Feb 2003
Externally published	Yes

Keywords

Cerebellar dysfunction
Dementia
Ketamine
N-Methyl-D-Aspartate receptor antagonist
Neurotoxicity
Status epilepticus

ASJC Scopus subject areas

Neurology
Clinical Neurology
Behavioral Neuroscience

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10.1016/S1525-5050(02)00643-1

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title = "Ketamine for refractory status epilepticus: A case of possible ketamine-induced neurotoxicity",

abstract = "A 44-year-old man with treated neurosyphilis presented with subclinical status epilepticus (SE) refractory to intravenous high-dose lorazepam, phenytoin, and valproic acid over 4 days. Ketamine infusion was instituted after low-dose propofol sedation with gradual control of electrographic seizures over 72 h. Reevaluation 3 months later revealed diffuse cerebellar and worsened cerebral atrophy, consistent with animal models of N-methyl-D-aspartate antagonist-mediated neurotoxicity. Animal studies of prolonged ketamine therapy are required before widespread human use in SE.",

keywords = "Cerebellar dysfunction, Dementia, Ketamine, N-Methyl-D-Aspartate receptor antagonist, Neurotoxicity, Status epilepticus",

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AU - Ubogu, Eroboghene E.

AU - Sagar, Stephen M.

AU - Lerner, Alan J.

AU - Maddux, Brian N.

AU - Suarez, José I.

AU - Werz, Mary Ann

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KW - Cerebellar dysfunction

KW - Dementia

KW - Ketamine

KW - N-Methyl-D-Aspartate receptor antagonist

KW - Neurotoxicity

KW - Status epilepticus

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Ketamine for refractory status epilepticus: A case of possible ketamine-induced neurotoxicity

Abstract

Keywords

ASJC Scopus subject areas

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