TY - JOUR
T1 - Kerosene intoxication
T2 - An experimental approach to the etiology of the CNS manifestations in primates
AU - Lietman, Paul S.
AU - Wolfsdorf, Jack
PY - 1976/6
Y1 - 1976/6
N2 - Baboons were utilized to investigate the clinicopathologic effects of kerosene, given via various routes, on the primate brain. The animals were divided into five groups: Group 1-normal controls; Group II-kerosene administered intratracheally; Group III-kerosene injected into left cardiac ventricle; Group IV-kerosene injected into right carotid artery; Group V-kerosene injected into portal vein. Results indicate that the primate brain is resistant to the direct toxic effects of kerosene. Even when the dose is very large, the microcirculations of the liver and lung filter out sufficient amounts of kerosene to protect the brain from damage. It is assumed that the CNS manifestations following ingestion of kerosene are due to hypoxia secondary to aspiration pneumonia.
AB - Baboons were utilized to investigate the clinicopathologic effects of kerosene, given via various routes, on the primate brain. The animals were divided into five groups: Group 1-normal controls; Group II-kerosene administered intratracheally; Group III-kerosene injected into left cardiac ventricle; Group IV-kerosene injected into right carotid artery; Group V-kerosene injected into portal vein. Results indicate that the primate brain is resistant to the direct toxic effects of kerosene. Even when the dose is very large, the microcirculations of the liver and lung filter out sufficient amounts of kerosene to protect the brain from damage. It is assumed that the CNS manifestations following ingestion of kerosene are due to hypoxia secondary to aspiration pneumonia.
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U2 - 10.1016/S0022-3476(76)81072-4
DO - 10.1016/S0022-3476(76)81072-4
M3 - Article
C2 - 818358
AN - SCOPUS:0017158440
VL - 88
SP - 1037
EP - 1040
JO - Journal of Pediatrics
JF - Journal of Pediatrics
SN - 0022-3476
IS - 6
ER -