Keratopathy after oral administration of tilorone hydrochloride

Jeffrey N. Weiss, Robert S. Weinberg, William Regelson

Research output: Contribution to journalArticle

Abstract

Two patients given tilorone HCl orally for varying periods of time had clinical and histopathologic ocular changes. Retrospective study of 14 cancer patients who were taking tilorone HCl orally revealed that three patients had similar ophthalmic findings accompanied by the appearance of blue halos around pinpoint light sources. Examination revealed a diffuse clouding of the epithelium sometimes associated with subepithelial infiltrates. Abnormalities seen histologically included cloudy swelling of the epithelium and cytoplasmic inclusions. By electron microscopy these were found to be myelinoid bodies. Gas chromatography and mass spectrophotometry showed that tilorone HCl was present in the cornea and conjunctiva. Visual acuity was not affected and these changes were slowly reversible with the cessation of therapy. Biomicroscopic and conjunctival cytologic examination may serve to indicate the drug's storage and potential damage in the body.

Original languageEnglish (US)
Pages (from-to)46-53
Number of pages8
JournalAmerican journal of ophthalmology
Volume89
Issue number1
DOIs
StatePublished - Jan 1980

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ASJC Scopus subject areas

  • Ophthalmology

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