Keratitis caused by candida glabrata in a patient with chronic granulomatous disease

Ali R. Djalilian; Janine A. Smith; Thomas J. Walsh; Harry L. Malech; Michael R. Robinson

doi:10.1016/S0002-9394(01)01091-1

Keratitis caused by candida glabrata in a patient with chronic granulomatous disease

Ali R. Djalilian, Janine A. Smith, Thomas J. Walsh, Harry L. Malech, Michael R. Robinson

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

PURPOSE: To report an unusual ocular presentation of Candida glabrata in a patient with chronic granulomatous disease. METHODS: Interventional case report. A 15-year-old boy with chronic granulomatous disease presented with bilateral limbal infiltrates. He had been receiving broad-spectrum systemic antibiotics for recurrent liver abscesses. The keratitis did not respond to antibiotics and did not resolve after a course of topical steroids. RESULTS: Corneal cultures revealed Candida glabrata. The same species was simultaneously isolated from the surgical drainage of the liver abscesses. The ocular and hepatic findings resolved on intravenous amphotericin B. CONCLUSION: Candida glabrata has recently emerged as an important nosocomial pathogen. It may present as a limbal keratitis in the setting of systemic infection.

Original language	English (US)
Pages (from-to)	782-783
Number of pages	2
Journal	American journal of ophthalmology
Volume	132
Issue number	5
DOIs	https://doi.org/10.1016/S0002-9394(01)01091-1
State	Published - 2001
Externally published	Yes

ASJC Scopus subject areas

Ophthalmology

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10.1016/S0002-9394(01)01091-1

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title = "Keratitis caused by candida glabrata in a patient with chronic granulomatous disease",

abstract = "PURPOSE: To report an unusual ocular presentation of Candida glabrata in a patient with chronic granulomatous disease. METHODS: Interventional case report. A 15-year-old boy with chronic granulomatous disease presented with bilateral limbal infiltrates. He had been receiving broad-spectrum systemic antibiotics for recurrent liver abscesses. The keratitis did not respond to antibiotics and did not resolve after a course of topical steroids. RESULTS: Corneal cultures revealed Candida glabrata. The same species was simultaneously isolated from the surgical drainage of the liver abscesses. The ocular and hepatic findings resolved on intravenous amphotericin B. CONCLUSION: Candida glabrata has recently emerged as an important nosocomial pathogen. It may present as a limbal keratitis in the setting of systemic infection.",

author = "Djalilian, {Ali R.} and Smith, {Janine A.} and Walsh, {Thomas J.} and Malech, {Harry L.} and Robinson, {Michael R.}",

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doi = "10.1016/S0002-9394(01)01091-1",

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volume = "132",

pages = "782--783",

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TY - JOUR

T1 - Keratitis caused by candida glabrata in a patient with chronic granulomatous disease

AU - Djalilian, Ali R.

AU - Smith, Janine A.

AU - Walsh, Thomas J.

AU - Malech, Harry L.

AU - Robinson, Michael R.

PY - 2001

Y1 - 2001

N2 - PURPOSE: To report an unusual ocular presentation of Candida glabrata in a patient with chronic granulomatous disease. METHODS: Interventional case report. A 15-year-old boy with chronic granulomatous disease presented with bilateral limbal infiltrates. He had been receiving broad-spectrum systemic antibiotics for recurrent liver abscesses. The keratitis did not respond to antibiotics and did not resolve after a course of topical steroids. RESULTS: Corneal cultures revealed Candida glabrata. The same species was simultaneously isolated from the surgical drainage of the liver abscesses. The ocular and hepatic findings resolved on intravenous amphotericin B. CONCLUSION: Candida glabrata has recently emerged as an important nosocomial pathogen. It may present as a limbal keratitis in the setting of systemic infection.

AB - PURPOSE: To report an unusual ocular presentation of Candida glabrata in a patient with chronic granulomatous disease. METHODS: Interventional case report. A 15-year-old boy with chronic granulomatous disease presented with bilateral limbal infiltrates. He had been receiving broad-spectrum systemic antibiotics for recurrent liver abscesses. The keratitis did not respond to antibiotics and did not resolve after a course of topical steroids. RESULTS: Corneal cultures revealed Candida glabrata. The same species was simultaneously isolated from the surgical drainage of the liver abscesses. The ocular and hepatic findings resolved on intravenous amphotericin B. CONCLUSION: Candida glabrata has recently emerged as an important nosocomial pathogen. It may present as a limbal keratitis in the setting of systemic infection.

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Keratitis caused by candida glabrata in a patient with chronic granulomatous disease

Abstract

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