Keratins Are Going Nuclear

Ryan P. Hobbs; Justin T. Jacob; Pierre A. Coulombe

doi:10.1016/j.devcel.2016.07.022

Keratins Are Going Nuclear

Ryan P. Hobbs, Justin T. Jacob, Pierre A. Coulombe

Bloomberg School of Public Health

Research output: Contribution to journal › Comment/debate › peer-review

25 Scopus citations

Abstract

Previously thought to reside exclusively in the cytoplasm, the cytoskeletal protein keratin 17 (K17) has been recently identified inside the nucleus of tumor epithelial cells with a direct impact on cell proliferation and gene expression. We comment on fundamental questions raised by this new finding and the associated significance.

Original language	English (US)
Pages (from-to)	227-233
Number of pages	7
Journal	Developmental Cell
Volume	38
Issue number	3
DOIs	https://doi.org/10.1016/j.devcel.2016.07.022
State	Published - Aug 8 2016

ASJC Scopus subject areas

Molecular Biology
General Biochemistry, Genetics and Molecular Biology
Developmental Biology
Cell Biology

Access to Document

10.1016/j.devcel.2016.07.022

Cite this

@article{c15a544d6a844c77b7d1ad4be797e92a,

title = "Keratins Are Going Nuclear",

abstract = "Previously thought to reside exclusively in the cytoplasm, the cytoskeletal protein keratin 17 (K17) has been recently identified inside the nucleus of tumor epithelial cells with a direct impact on cell proliferation and gene expression. We comment on fundamental questions raised by this new finding and the associated significance.",

author = "Hobbs, {Ryan P.} and Jacob, {Justin T.} and Coulombe, {Pierre A.}",

note = "Funding Information: The authors are grateful to laboratory and departmental colleagues for stimulating discussions and to Drs. Carole Parent and Michael Matunis for reading the manuscript. Relevant efforts in the Coulombe laboratory are supported by grants AR044232 and CA160255 from the National Institutes of Health . Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",

year = "2016",

month = aug,

day = "8",

doi = "10.1016/j.devcel.2016.07.022",

language = "English (US)",

volume = "38",

pages = "227--233",

journal = "Developmental Cell",

issn = "1534-5807",

publisher = "Cell Press",

number = "3",

}

TY - JOUR

T1 - Keratins Are Going Nuclear

AU - Hobbs, Ryan P.

AU - Jacob, Justin T.

AU - Coulombe, Pierre A.

N1 - Funding Information: The authors are grateful to laboratory and departmental colleagues for stimulating discussions and to Drs. Carole Parent and Michael Matunis for reading the manuscript. Relevant efforts in the Coulombe laboratory are supported by grants AR044232 and CA160255 from the National Institutes of Health . Publisher Copyright: © 2016 Elsevier Inc.

PY - 2016/8/8

Y1 - 2016/8/8

N2 - Previously thought to reside exclusively in the cytoplasm, the cytoskeletal protein keratin 17 (K17) has been recently identified inside the nucleus of tumor epithelial cells with a direct impact on cell proliferation and gene expression. We comment on fundamental questions raised by this new finding and the associated significance.

AB - Previously thought to reside exclusively in the cytoplasm, the cytoskeletal protein keratin 17 (K17) has been recently identified inside the nucleus of tumor epithelial cells with a direct impact on cell proliferation and gene expression. We comment on fundamental questions raised by this new finding and the associated significance.

UR - http://www.scopus.com/inward/record.url?scp=84989841260&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84989841260&partnerID=8YFLogxK

U2 - 10.1016/j.devcel.2016.07.022

DO - 10.1016/j.devcel.2016.07.022

M3 - Comment/debate

C2 - 27505414

AN - SCOPUS:84989841260

SN - 1534-5807

VL - 38

SP - 227

EP - 233

JO - Developmental Cell

JF - Developmental Cell

IS - 3

ER -

Keratins Are Going Nuclear

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this