Keratins Are Going Nuclear

Ryan P. Hobbs; Justin T. Jacob; Pierre A. Coulombe

doi:10.1016/j.devcel.2016.07.022

Keratins Are Going Nuclear

Ryan P. Hobbs, Justin T. Jacob, Pierre A. Coulombe

Bloomberg School of Public Health

Research output: Contribution to journal › Comment/debate › peer-review

25 Scopus citations

Abstract

Previously thought to reside exclusively in the cytoplasm, the cytoskeletal protein keratin 17 (K17) has been recently identified inside the nucleus of tumor epithelial cells with a direct impact on cell proliferation and gene expression. We comment on fundamental questions raised by this new finding and the associated significance.

Original language	English (US)
Pages (from-to)	227-233
Number of pages	7
Journal	Developmental Cell
Volume	38
Issue number	3
DOIs	https://doi.org/10.1016/j.devcel.2016.07.022
State	Published - Aug 8 2016

ASJC Scopus subject areas

Molecular Biology
Biochemistry, Genetics and Molecular Biology(all)
Developmental Biology
Cell Biology

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10.1016/j.devcel.2016.07.022

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title = "Keratins Are Going Nuclear",

abstract = "Previously thought to reside exclusively in the cytoplasm, the cytoskeletal protein keratin 17 (K17) has been recently identified inside the nucleus of tumor epithelial cells with a direct impact on cell proliferation and gene expression. We comment on fundamental questions raised by this new finding and the associated significance.",

author = "Hobbs, {Ryan P.} and Jacob, {Justin T.} and Coulombe, {Pierre A.}",

note = "Funding Information: The authors are grateful to laboratory and departmental colleagues for stimulating discussions and to Drs. Carole Parent and Michael Matunis for reading the manuscript. Relevant efforts in the Coulombe laboratory are supported by grants AR044232 and CA160255 from the National Institutes of Health . Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",

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AU - Hobbs, Ryan P.

AU - Jacob, Justin T.

AU - Coulombe, Pierre A.

N1 - Funding Information: The authors are grateful to laboratory and departmental colleagues for stimulating discussions and to Drs. Carole Parent and Michael Matunis for reading the manuscript. Relevant efforts in the Coulombe laboratory are supported by grants AR044232 and CA160255 from the National Institutes of Health . Publisher Copyright: © 2016 Elsevier Inc.

PY - 2016/8/8

Y1 - 2016/8/8

N2 - Previously thought to reside exclusively in the cytoplasm, the cytoskeletal protein keratin 17 (K17) has been recently identified inside the nucleus of tumor epithelial cells with a direct impact on cell proliferation and gene expression. We comment on fundamental questions raised by this new finding and the associated significance.

AB - Previously thought to reside exclusively in the cytoplasm, the cytoskeletal protein keratin 17 (K17) has been recently identified inside the nucleus of tumor epithelial cells with a direct impact on cell proliferation and gene expression. We comment on fundamental questions raised by this new finding and the associated significance.

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Keratins Are Going Nuclear

Abstract

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