The remarkable ability, of skin epithelia to maintain their integrity in the face of repeated mechanical stress resides in port in on intricate network of keratin filaments located in the cytoplasm of its constituent cells. The experimental evidence in support of the crucial scaffolding function provided by keratin filament networks has grown steadily in the last decode, and include the study of several epithelial fragility disorders associated with inherited mutations affecting keratin genes. More recent studies focused on keratin polymer function during embryonic skin development and the wound repair response in adult skin. Their outcome suggests that keratins, and more particularly K6, K16 and K17, may play additional, perhaps more subtle, roles in epithelial differentiation. Sustained studies of keratin genes and their proteins will undoudtedly continue to provide significant insights in the biology of skin and related complex epithelia.
|Translated title of the contribution||Keratin, new insights in skin biology|
|Number of pages||10|
|State||Published - 2002|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)