Keeping track of time: The fundamentals of cellular clocks

Colin R. Gliech, Andrew J. Holland

Research output: Contribution to journalReview articlepeer-review


Biological timekeeping enables the coordination and execution of complex cellular processes such as developmental programs, day/night organismal changes, intercellular signaling, and proliferative safeguards. While these systems are often considered separately owing to a wide variety of mechanisms, time frames, and outputs, all clocks are built by calibrating or delaying the rate of biochemical reactions and processes. In this review, we explore the common themes and core design principles of cellular clocks, giving special consideration to the challenges associated with building timers from biochemical components. We also outline how evolution has coopted time to increase the reliability of a diverse range of biological systems.

Original languageEnglish (US)
Article numbere202005136
JournalJournal of Cell Biology
Issue number11
StatePublished - Sep 2020

ASJC Scopus subject areas

  • Cell Biology


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